Catalog: YD2232
Size
Price
Status
Qty.
1mg
$4,470.00
3 weeks
0
100μg
$745.00
3 weeks
0
Add to cart
Collected
Collect
Detailed Information
Recommended Dilution Ratio
Reconstitute in sterile water for a stock solution
Formulation
Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.
Source
Mammalian cells
Purity
>90% as determined by SDS-PAGE
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Antigen&Target Information
Sequence:
A DNA sequence encoding the human ERBB2(Met1-Thr652) was fused with the C-terminal His Tag
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Other Name:
HER-2,HER-2/neu,HER2,MLN 19,MLN19,NEU,NGL,TKR1
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Cellular Localization:
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein. Early endosome . Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). .; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.
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Tissue Expression:
Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
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Signaling Pathway
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Cellular Processes >> Cellular community - eukaryotes >> Adherens junction
Cellular Processes >> Cellular community - eukaryotes >> Tight junction
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: overview >> MicroRNAs in cancer
Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer
Human Diseases >> Cancer: specific types >> Pancreatic cancer
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Bladder cancer
Human Diseases >> Cancer: specific types >> Prostate cancer
Human Diseases >> Cancer: specific types >> Endometrial cancer
Human Diseases >> Cancer: specific types >> Breast cancer
Human Diseases >> Cancer: specific types >> Non-small cell lung cancer
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> ErbB signaling pathway
Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Reference Citation({{totalcount}})
Catalog: YD2232
Size
Price
Status
Qty.
1mg
$4,470.00
3 weeks
0
100μg
$745.00
3 weeks
0
Add to cart
Collected
Collect
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