CDK2

Cyclin-dependent kinase 2 ;
Cell division protein kinase 2 ;
p33 protein kinase ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme , while phosphorylation at Thr-160 activates it. ,function:Involved in the control of the cell cycle. Interacts with cyclins A , B1 , B3 , D , or E. Activity of CDK2 is maximal during S phase and G2. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Found in a complex with CABLES1 , CCNA1 and CCNE1. Interacts with CABLES1 (By similarity) . Interacts with UHRF2. Part of a complex consisting of UHRF2 , CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1. ,

G1 phase of mitotic cell cycle , G2/M transition of mitotic cell cycle , M phase of mitotic cell cycle , mitotic cell cycle , M phase , nuclear division , DNA metabolic process , DNA replication , regulation of DNA replication , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , ion transport , cation transport ,potassium ion transport , cell cycle , mitosis , traversing start control point of mitotic cell cycle , regulation of mitotic cell cycle , positive regulation of cell proliferation , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , monovalent inorganic cation transport , phosphorylation , cell cycle process , cell cycle phase , metal ion transport , positive regulation of cellular biosynthetic process , regulation of cell proliferation , regulation of transcription , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , organelle fission , regulation of DNA metabolic process , positive regulation of nitrogen compound metabolic process , cell division , G1 phase , interphase , interphase of mitotic cell cycle , regulation of cell cycle ,

Cytoplasm , cytoskeleton , microtubule organizing center , centrosome. Nucleus , Cajal body. Cytoplasm. Endosome. Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1 ,25- (OH) (2) D (3) .