Catalog: YD2207
Size
Price
Status
Qty.
1mg
$4,320.00
3 weeks
0
100μg
$720.00
3 weeks
0
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Detailed Information
Recommended Dilution Ratio
Reconstitute in sterile water for a stock solution
Formulation
Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.
Source
E.coli
Purity
>90% as determined by SDS-PAGE
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Antigen&Target Information
Sequence:
A DNA sequence encoding the human IL18(Tyr37-Asp193) was fused with the C-terminal His Tag
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Other Name:
IGIF, IL1F4
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Cellular Localization:
Cytoplasm . Secreted . The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .
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Signaling Pathway
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway
Human Diseases >> Immune disease >> Rheumatoid arthritis
Human Diseases >> Immune disease >> Inflammatory bowel disease
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Reference Citation({{totalcount}})
Catalog: YD2207
Size
Price
Status
Qty.
1mg
$4,320.00
3 weeks
0
100μg
$720.00
3 weeks
0
Add to cart
Collected
Collect
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