Catalog: KA1180C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
PTPN6
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Other Name:
Tyrosine-protein phosphatase non-receptor type 6 ;
Hematopoietic cell protein-tyrosine phosphatase ;
Protein-tyrosine phosphatase 1C ;
PTP-1C ;
Protein-tyrosine phosphatase SHP-1 ;
SH-PTP1 ;
Hematopoietic cell protein-tyrosine phosphatase ;
Protein-tyrosine phosphatase 1C ;
PTP-1C ;
Protein-tyrosine phosphatase SHP-1 ;
SH-PTP1 ;
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Database Link:
Background:
catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate. ,function:Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1 , induces UBE2V2 expression upon angiotensin II stimulation. ,PTM:Phosphorylated on serine and tyrosine residues. ,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. ,similarity:Contains 1 tyrosine-protein phosphatase domain. ,similarity:Contains 2 SH2 domains. ,subcellular location:In neurons , translocates into the nucleus after treatment with angiotensin II. ,subunit:Monomer. Interacts with MTUS1 (By similarity) . Binds PTPNS1 , LILRB1 and LILRB2. Interacts with FCRL2 , FCRL3 , FCRL4 , CD300LF and CD84. ,tissue specificity:Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in non-hematopoietic cells. ,
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Function:
protein amino acid dephosphorylation , phosphorus metabolic process , phosphate metabolic process , apoptosis , cell surface receptor linked signal transduction , G-protein coupled receptor protein signaling pathway , cell death , negative regulation of cell proliferation , response to wounding , programmed cell death , death , dephosphorylation , regulation of cell proliferation ,
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Cellular Localization:
Cytoplasm. Nucleus. In neurons , translocates into the nucleus after treatment with angiotensin II (By similarity) . Shuttles between the cytoplasm and nucleus via its association with PDPK1. .
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Tissue Expression:
Signaling Pathway
Cellular Processes >> Cellular community - eukaryotes >> Adherens junction
Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Organismal Systems >> Immune system >> T cell receptor signaling pathway
Organismal Systems >> Immune system >> B cell receptor signaling pathway
Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
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Catalog: KA1180C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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