Catalog: YD2203
Size
Price
Status
Qty.
1mg
$4,320.00
3 weeks
0
100μg
$720.00
3 weeks
0
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Collected
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Detailed Information
Recommended Dilution Ratio
Reconstitute in sterile water for a stock solution
Formulation
Supplied as solution form in PBS pH7.5./ Lyophilized from PBS pH7.5.
Source
E.coli
Purity
>90% as determined by SDS-PAGE
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Antigen&Target Information
Sequence:
A DNA sequence encoding the human IL1B(Ala117~Ser269) was fused with the C-terminal His Tag
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Other Name:
IL1F2
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Cellular Localization:
Cytoplasm, cytosol . Secreted . Lysosome . Secreted, extracellular exosome . The precursor is cytosolic (PubMed:15192144). In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted (PubMed:24201029, PubMed:33377178, PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .
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Tissue Expression:
Expressed in activated monocytes/macrophages (at protein level).
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Immune system >> Hematopoietic cell lineage
Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway
Organismal Systems >> Immune system >> Th17 cell differentiation
Organismal Systems >> Immune system >> IL-17 signaling pathway
Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels
Organismal Systems >> Development and regeneration >> Osteoclast differentiation
Human Diseases >> Immune disease >> Rheumatoid arthritis
Human Diseases >> Immune disease >> Inflammatory bowel disease
Human Diseases >> Immune disease >> Graft-versus-host disease
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Prion disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway
Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Reference Citation({{totalcount}})
Catalog: YD2203
Size
Price
Status
Qty.
1mg
$4,320.00
3 weeks
0
100μg
$720.00
3 weeks
0
Add to cart
Collected
Collect
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