Catalog: KA1171C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Collected
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
NFKBIE;IKBE
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Other Name:
NF-kappa-B inhibitor epsilon ;
NF-kappa-BIE ;
I-kappa-B-epsilon ;
IkB-E ;
IkB-epsilon ;
IkappaBepsilon ;
NF-kappa-BIE ;
I-kappa-B-epsilon ;
IkB-E ;
IkB-epsilon ;
IkappaBepsilon ;
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Background:
function:Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. ,PTM:Serine phosphorylated; followed by proteasome-dependent degradation. ,similarity:Belongs to the NF-kappa-B inhibitor family. ,similarity:Contains 6 ANK repeats. ,subunit:Interacts with RELA , REL , NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. ,tissue specificity:Highly expressed in spleen , testis and lung , followed by kidney , pancreas , heart , placenta and brain. Also expressed in granulocytes and macrophages. ,
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Function:
amino acid transport , protein localization , neutral amino acid transport , amine transport , organic acid transport , serine transport , regulation of intracellular transport , negative regulation of intracellular transport , maintenance of protein location in cell , regulation of protein localization , regulation of intracellular protein transport , regulation of protein import into nucleus , negative regulation of protein import into nucleus , D-amino acid transport , D-serine transport ,regulation of transcription factor import into nucleus , negative regulation of transcription factor import into nucleus ,cytoplasmic sequestering of transcription factor , maintenance of protein location , regulation of nucleocytoplasmic transport , negative regulation of nucleocytoplasmic transport , carboxylic acid transport , negative regulation of transport , cytoplasmic sequestering of protein , regulation of protein transport , negative regulation of protein transport , maintenance of location , maintenance of location in cell , regulation of cellular localization , regulation of establishment of protein localization ,
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Cellular Localization:
Cytoplasm .
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Signaling Pathway
Organismal Systems >> Immune system >> T cell receptor signaling pathway
Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation
Organismal Systems >> Immune system >> Th17 cell differentiation
Organismal Systems >> Immune system >> B cell receptor signaling pathway
Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer
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Catalog: KA1171C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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