HSP90AB1

Heat shock protein HSP 90-beta ;
HSP 90 ;
Heat shock 84 kDa ;
HSP 84 ;
HSP84 ;

function:Molecular chaperone. Has ATPase activity. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the heat shock protein 90 family. ,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV. ,subunit:Homodimer. Interacts with TP53/p53 (By similarity) . Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. ,

regulation of cytokine-mediated signaling pathway , protein folding , response to unfolded protein , positive regulation of biosynthetic process , regulation of catabolic process , negative regulation of catabolic process , response to organic substance , negative regulation of macromolecule metabolic process , regulation of proteolysis , positive regulation of cellular biosynthetic process , regulation of cellular catabolic process , negative regulation of cellular catabolic process ,regulation of cellular protein metabolic process , negative regulation of cellular protein metabolic process , regulation of proteasomal ubiquitin-dependent protein catabolic process , negative regulation of proteasomal ubiquitin-dependent protein catabolic process , regulation of protein catabolic process , negative regulation of protein catabolic process ,regulation of nitric oxide biosynthetic process , positive regulation of nitric oxide biosynthetic process , negative regulation of proteolysis , positive regulation of nitrogen compound metabolic process , negative regulation of protein metabolic process , response to protein stimulus , regulation of interferon-gamma-mediated signaling pathway ,regulation of type I interferon-mediated signaling pathway ,

Cytoplasm . Melanosome . Nucleus . Secreted . Cell membrane . Dynein axonemal particle . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) . Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673) . Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762) . .