EFNB1/EFNB2

disease:Defects in EFNB1 are a cause of craniofrontonasal syndrome (CFNS) [MIM:304110]; also known as craniofrontonasal dysplasia (CFND) . CFNS is an X-linked inherited syndrome characterized by hypertelorism , coronal synostosis with brachycephaly , downslanting palpebral fissures , clefting of the nasal tip , joint anomalies , longitudinally grooved fingernails and other digital anomalies. ,function:Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to , and induce the collapse of , commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. ,induction:By TNF-alpha. ,PTM:Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. ,similarity:Belongs to the ephrin family. ,subunit:Interacts with GRIP1 and GRIP2. ,tissue specificity:Heart , placenta , lung , liver , skeletal muscle , kidney , pancreas. ,

cell morphogenesis , cell morphogenesis involved in differentiation , ameboidal cell migration , neural crest cell migration ,positive regulation of immune system process , regulation of leukocyte activation , positive regulation of leukocyte activation , cell motion , cell adhesion , cell-cell signaling , pattern specification process , axonogenesis , axon guidance ,positive regulation of cell proliferation , embryonic pattern specification , mesenchymal cell development , neural crest cell development , neural crest cell differentiation , cell migration , biological adhesion , cell projection organization ,neuron differentiation , neuron projection development , regulation of mononuclear cell proliferation , positive regulation of mononuclear cell proliferation , cellular component morphogenesis , cell part morphogenesis , positive regulation of T cell proliferation , regulation of cell proliferation , regulation of T cell proliferation , neuron development , cell morphogenesis involved in neuron differentiation , mesenchymal cell differentiation , neuron projection morphogenesis ,cell projection morphogenesis , cell motility , regulation of lymphocyte proliferation , positive regulation of lymphocyte proliferation , regulation of T cell activation , regulation of cell activation , positive regulation of cell activation , positive regulation of T cell activation , regulation of lymphocyte activation , positive regulation of lymphocyte activation ,localization of cell , mesenchyme development , regulation of leukocyte proliferation , positive regulation of leukocyte proliferation ,

Cell membrane ; Single-pass type I membrane protein . Membrane raft . May recruit GRIP1 and GRIP2 to membrane raft domains. .; [Ephrin-B1 C-terminal fragment]: Cell membrane ; Single-pass type I membrane protein .; [Ephrin-B1 intracellular domain]: Nucleus . Colocalizes with ZHX2 in the nucleus. .