Catalog: YD2187
Size
Price
Status
Qty.
1mg
$800.00
3 weeks
0
100μg
$300.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Reactivity
Human virus
Applications
ELISA, ECL, Immunogold,
MW
22kD (Calculated)
Detailed Information
Recommended Dilution Ratio
Testing in progress
Source
E.coli
Purity
>90% as determined by SDS-PAGE
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
MW(Calculated)
22kD
Antigen&Target Information
Gene Name:
ORF1ab
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Protein Name:
nsp3,PL-PRO,Papain-like proteinase,X domain（Macro domain）
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Database Link:
| Organism | Gene ID | SwissProt |
|---|---|---|
| Human | QHD43415.1; |
Background:
Recombinant SARS-CoV-2 NSP3 is produced by E.coli expression system and the target gene encoding Glu1024-Gln1198 is expressed with N-His Tag
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Function:
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
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Research Areas:
For research use only .Not for use in clinical diagnostic procedures.
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Reference Citation({{totalcount}})
Catalog: YD2187
Size
Price
Status
Qty.
1mg
$800.00
3 weeks
0
100μg
$300.00
3 weeks
0
Add to cart
Collected
Collect
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