AAPK1/AAPK2

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Binding of AMP results in allosteric activation , inducing phosphorylation on Thr-174 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions , without detectable changes in the AMP/ATP ratio. ,function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. ,sequence caution:Translation N-terminally shortened. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Heterotrimer of an alpha catalytic subunit , a beta and a gamma non-catalytic subunits. Interacts with FNIP1 and FNIP2. ,

MAPKKK cascade , activation of MAPK activity , response to hypoxia , monosaccharide metabolic process , glucose metabolic process , protein amino acid phosphorylation , fatty acid metabolic process , fatty acid biosynthetic process ,steroid biosynthetic process , cholesterol biosynthetic process , phosphorus metabolic process , phosphate metabolic process , intracellular signaling cascade , protein kinase cascade , steroid metabolic process , cholesterol metabolic process , lipid biosynthetic process , negative regulation of biosynthetic process , positive regulation of biosynthetic process , regulation of cellular ketone metabolic process , positive regulation of steroid biosynthetic process , organic acid biosynthetic process , sterol metabolic process , sterol biosynthetic process , phosphorylation , regulation of lipid metabolic process , regulation of fatty acid metabolic process , regulation of steroid metabolic process , regulation of phosphate metabolic process , hexose metabolic process , fatty acid oxidation , lipid modification , negative regulation of cellular biosynthetic process , positive regulation of kinase activity , lipid oxidation , regulation of phosphorylation ,positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity ,regulation of kinase activity , regulation of cellular component biogenesis , positive regulation of molecular function ,regulation of cholesterol biosynthetic process , positive regulation of cholesterol biosynthetic process , regulation of anti-apoptosis , positive regulation of anti-apoptosis , negative regulation of lipid metabolic process , positive regulation of lipid metabolic process , regulation of protein kinase activity , positive regulation of protein kinase activity , positive regulation of steroid metabolic process , regulation of glucosylceramide biosynthetic process , negative regulation of glucosylceramide biosynthetic process , regulation of fatty acid oxidation , carboxylic acid biosynthetic process , positive regulation of lipid biosynthetic process , regulation of lipid biosynthetic process , regulation of steroid biosynthetic process , negative regulation of lipid biosynthetic process , regulation of phosphorus metabolic process , regulation of transferase activity , positive regulation of transferase activity , response to oxygen levels ,

Cytoplasm . Nucleus . In response to stress , recruited by p53/TP53 to specific promoters. .