ADD1/ADD2

alternative products:Additional isoforms seem to exist ,domain:Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region , a short connecting subdomain , and a protease-sensitive tail region. ,function:Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. ,PTM:The N-terminus is blocked. ,similarity:Belongs to the aldolase class II family. Adducin subfamily. ,subunit:Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Binds ROCK1. ,tissue specificity:Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit. ,

cell morphogenesis , in utero embryonic development , tissue homeostasis , immune system development , cell volume homeostasis , cytoskeleton organization , actin filament organization , regulation of actin polymerization or depolymerization , embryonic development ending in birth or egg hatching , negative regulation of organelle organization , cellular homeostasis , hemoglobin metabolic process , actin filament-based process , actin cytoskeleton organization , hemopoiesis , myeloid cell differentiation , erythrocyte differentiation , regulation of actin filament length ,regulation of actin filament polymerization , regulation of actin filament depolymerization , negative regulation of actin filament depolymerization , negative regulation of actin filament polymerization , negative regulation of protein complex assembly , positive regulation of protein binding , regulation of protein polymerization , negative regulation of protein polymerization , regulation of cellular component size , regulation of actin cytoskeleton organization , regulation of actin filament-based process , cellular component morphogenesis , regulation of organelle organization , erythrocyte homeostasis , multicellular organism growth , growth , homeostatic process , chordate embryonic development , negative regulation of protein complex disassembly , regulation of protein complex disassembly , regulation of protein complex assembly , regulation of protein binding , regulation of cellular component biogenesis , positive regulation of molecular function , hemopoietic or lymphoid organ development , multicellular organismal homeostasis , homeostasis of number of cells , homeostasis of number of cells within a tissue , barbed-end actin filament capping , actin filament bundle formation , regulation of binding , positive regulation of binding , negative regulation of cellular component organization ,regulation of cytoskeleton organization , negative regulation of cytoskeleton organization , actin filament capping ,anatomical structure homeostasis ,

Cytoplasm , cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.