Catalog: KA1159C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Main Information
Reactivity
Human
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CASP2
show all
Other Name:
Caspase-2 ;
CASP-2 ;
Neural precursor cell expressed developmentally down-regulated protein 2 ;
NEDD-2 ;
Protease ICH-1 ;
[Cleaved into: Caspase-2 subunit p18 ;
Caspase-2 subunit p13 ;
Caspase-2 subunit p12]
CASP-2 ;
Neural precursor cell expressed developmentally down-regulated protein 2 ;
NEDD-2 ;
Protease ICH-1 ;
[Cleaved into: Caspase-2 subunit p18 ;
Caspase-2 subunit p13 ;
Caspase-2 subunit p12]
show all
Background:
alternative products:Isoforms differ in the N- and C-termini ,catalytic activity:Strict requirement for an Asp residue at P1 , with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-. ,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. ,PTM:The mature protease can process its own propeptide , but not that of other caspases. ,similarity:Belongs to the peptidase C14A family. ,similarity:Contains 1 CARD domain. ,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers , each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. ,tissue specificity:Expressed at higher levels in the embryonic lung , liver and kidney than in the heart and brain. In adults , higher level expression is seen in the placenta , lung , kidney , and pancreas than in the heart , brain , liver and skeletal muscle. ,
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Function:
proteolysis , apoptosis , anti-apoptosis , induction of apoptosis , cell death , induction of apoptosis by extracellular signals , regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death , death , protein processing , regulation of apoptosis , positive regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of programmed cell death , protein maturation , protein maturation by peptide bond cleavage , negative regulation of cell death ,
show all
Signaling Pathway
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Catalog: KA1159C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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