SP1

Transcription factor Sp1

function:Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Can interact with G/C-rich motifs from serotonin receptor promoter. ,PTM:O-glycosylated; contains N-acetylglucosamine side chains. ,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family. ,similarity:Contains 3 C2H2-type zinc fingers. ,subunit:Interacts with ATF7IP , ATF7IP2 , POGZ , HCFC1 , AATF and PHC2. Interacts with varicella-zoster virus IE62 protein and HIV-1 Vpr. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the two proteins in DNA binding. ,

skeletal system development , ossification , eye development , in utero embryonic development , blastocyst development , blastocyst formation , trophectodermal cell differentiation , liver development , placenta development ,embryonic placenta development , immune system development , transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , regulation of transcription from RNA polymerase II promoter , global , sensory organ development , female pregnancy , embryonic development ending in birth or egg hatching , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , hemopoiesis ,myeloid cell differentiation , erythrocyte differentiation , megakaryocyte differentiation , respiratory tube development ,lung development , embryonic camera-type eye development , positive regulation of cellular biosynthetic process ,multicellular organism reproduction , erythrocyte homeostasis , tube development , homeostatic process , chordate embryonic development , camera-type eye development , enucleate erythrocyte differentiation , regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , global , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter ,embryonic eye morphogenesis , hemopoietic or lymphoid organ development , embryonic organ morphogenesis ,embryonic organ development , eye morphogenesis , camera-type eye morphogenesis , embryonic camera-type eye morphogenesis , embryonic morphogenesis , reproductive process in a multicellular organism , embryonic skeletal system development , homeostasis of number of cells , positive regulation of nitrogen compound metabolic process ,regulation of RNA metabolic process , positive regulation of RNA metabolic process , embryonic process involved in female pregnancy , definitive hemopoiesis , bone development , respiratory system development ,

Nucleus. Cytoplasm. Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location , while glucagon favors cytoplasmic location.