Contact Us

408-747-0189
1-877-594-3616

Quick order
Catalog: YD0105
Size
Price
Status
Qty.
100μg
$280.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service
Main Information
Reactivity

Human

Applications

WB, SDS-PAGE

Detailed Information
Formulation
Liquid in PBS
Purity
SDS-PAGE >90%
Storage
-20°C/6 month,-80°C for long storage
Related Products
Primary Antibodies
Stat4 Rabbit pAb
YT4447

More→

Primary Antibodies
Stat4 (Phospho Tyr693) Rabbit pAb
YP0593

More→

Primary Antibodies
Stat4 (Phospho Tyr693) Rabbit pAb
YP0252

More→

ELISA Kits
Total STAT4 Cell-Based Colorimetric ELISA Kit
KA4292C

More→

ELISA Kits
STAT4 (Phospho Tyr693) Cell-Based Colorimetric ELISA Kit
KA1195C

More→

Antigen&Target Information
Sequence:
Amino acid: 506-748, with his-MBP tag.
show all
Gene Name:
STAT4
show all
Protein Name:
STAT4 protein
show all
Other Name:
Signal transducer and activator of transcription 4
show all
Database Link:
Organism Gene ID SwissProt
Human 6775; Q14765;
Mouse P42228;
Background:
disease:Genetic variations in STAT4 are associated with susceptibility to rheumatoid arthritis (RA) [MIM:180300]. Rheumatoid arthritis is a complex, multifactorial disorder. It is one of the most common autoimmune diseases and it is characterized by inflammation of synovial tissue and joint destruction.,disease:Genetic variations in STAT4 are associated with susceptibility to systemic lupus erythematosus type 11 (SLEB11) [MIM:612253]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.,PTM:Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity). The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.,
show all
Function:
transcription, regulation of transcription, DNA-dependent, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, protein kinase cascade, JAK-STAT cascade, cell proliferation, phosphorylation, cytokine-mediated signaling pathway, regulation of transcription, regulation of RNA metabolic process,
show all
Cellular Localization:
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
show all
Catalog: YD0105
Size
Price
Status
Qty.
100μg
$280.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

Toggle night Mode

{{pinfoXq.title || ''}}

Catalog: {{pinfoXq.catalog || ''}}
Filter:

All

{{item.name}}

{{pinfo.title}}
-{{pinfo.catalog}}

Filter:

{{item.descr}}

Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Learn more
Product {{index}}/{{pcount}}
Prev
Next

{{pvTitle}}

Scroll wheel zooms the picture
{{pvDescr}}