RELB

Transcription factor RelB ;
I-Rel ;

caution:Was originally (PubMed:1577270) thought to inhibit the transcriptional activity of nuclear factor NF-kappa-B. ,domain:Both N- and C-terminal domains are required for transcriptional activation. ,function:NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation , immunity , differentiation , cell growth , tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65 , RELB , NFKB1/p105 , NFKB1/p50 , REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors , respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway , I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators , subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. ,induction:By mitogens. ,PTM:Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation. ,similarity:Contains 1 RHD (Rel-like) domain. ,subunit:Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50 , NFKB2/p52 and NFKB2/p100. Interacts with NFKBID. ,

myeloid dendritic cell activation , cell activation , adaptive immune response , cell activation during immune response ,myeloid leukocyte activation , lymphocyte activation during immune response , T cell activation during immune response , alpha-beta T cell activation during immune response , T cell differentiation during immune response , alpha-beta T cell differentiation during immune response , CD4-positive , alpha-beta T cell differentiation during immune response , leukocyte activation during immune response , adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , immune system development , leukocyte differentiation , myeloid leukocyte differentiation , transcription , regulation of transcription , DNA-dependent , immune response , antigen processing and presentation , hemopoiesis , lymphocyte differentiation , myeloid cell differentiation , T cell differentiation , T-helper 1 type immune response , T-helper cell differentiation , T cell activation , myeloid dendritic cell differentiation , CD4-positive , alpha beta T cell differentiation , T-helper 1 cell differentiation , leukocyte activation ,regulation of transcription , alpha-beta T cell activation , alpha-beta T cell differentiation , lymphocyte activation ,hemopoietic or lymphoid organ development , regulation of RNA metabolic process ,

Nucleus . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Colocalizes with NEK6 in the centrosome.