TP73

Tumor protein p73 ;
p53-like transcription factor ;
p53-related protein ;

cofactor:Binds 1 zinc ion per subunit. ,disease:Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be frequently mutated in human cancers , in contrast to p53. Hemizygosity is observed in neuroblastoma and oligodendroglioma. ,domain:Possesses an acidic transactivation domain , a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain. ,domain:The WW-binding motif mediates interaction with WWOX. ,function:Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic , isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. ,induction:Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction. ,miscellaneous:Activated and stabilized by interaction with RANBP9. ,PTM:Isoform alpha (but not isoform beta) is sumoylated on Lys-627 , which potentiates proteasomal degradation but does not affect transcriptional activity. ,similarity:Belongs to the p53 family. ,similarity:Contains 1 SAM (sterile alpha motif) domain. ,subcellular location:Accumulates in the nucleus in response to DNA damage. ,subunit:Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53 , whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma , isoform Alpha , and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Isoform Beta interacts with WWOX. ,tissue specificity:Brain , kidney , placenta , colon , heart , liver , spleen , skeletal muscle , prostate , thymus and pancreas. Highly expressed in fetal tissue. ,

regulation of cell growth , release of cytochrome c from mitochondria , regulation of protein amino acid phosphorylation ,response to tumor cell , DNA metabolic process , DNA repair , mismatch repair , transcription , regulation of transcription , DNA-dependent , negative regulation of protein kinase activity , apoptosis , induction of apoptosis , defense response ,inflammatory response , response to DNA damage stimulus , mitochondrion organization , cell cycle , cell cycle arrest ,intracellular signaling cascade , body fluid secretion , cell death , regulation of cell size , induction of apoptosis by intracellular signals , DNA damage response , signal transduction resulting in induction of apoptosis , apoptotic mitochondrial changes , response to wounding , post-embryonic development , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , regulation of protein kinase cascade , positive regulation of gene expression , regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death , death , regulation of phosphate metabolic process , telencephalon development , pallium development , limbic system development , hippocampus development , cell cycle process , neuron differentiation , negative regulation of cell growth , forebrain development ,positive regulation of cellular biosynthetic process , regulation of protein modification process , regulation of cellular protein metabolic process , regulation of cellular component size , cerebrospinal fluid secretion , cellular response to stress , negative regulation of kinase activity , regulation of growth , regulation of phosphorylation , DNA damage response , signal transduction , regulation of apoptosis , positive regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of programmed cell death , negative regulation of catalytic activity , regulation of MAP kinase activity , negative regulation of MAP kinase activity , regulation of MAPKKK cascade , regulation of JUN kinase activity , negative regulation of JUN kinase activity , regulation of neuron apoptosis , negative regulation of neuron apoptosis , regulation of kinase activity ,negative regulation of molecular function , regulation of transcription , negative regulation of cell size , positive regulation of cell size , regulation of protein kinase activity , positive regulation of transcription , DNA-dependent ,negative regulation of growth , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , regulation of JNK cascade , secretion , digestive tract morphogenesis ,neuron development , regulation of body fluid levels , positive regulation of nitrogen compound metabolic process ,regulation of phosphorus metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of transferase activity , negative regulation of transferase activity , digestive system development ,negative regulation of cell death , regulation of stress-activated protein kinase signaling pathway , regulation of cellular response to stress ,

Nucleus . Cytoplasm. Accumulates in the nucleus in response to DNA damage.