Amino acid: 287-441, with his-MBP tag.

PPARD NR1C2 PPARB

PPAR delta protein

Peroxisome proliferator-activated receptor delta ;
PPAR-delta ;
NUCI ;
Nuclear hormone receptor 1 ;
NUC1 ;
Nuclear receptor subfamily 1 group C member 2 ;
Peroxisome proliferator-activated receptor beta ;
PPAR-beta ;

peroxisome proliferator activated receptor delta(PPARD) Homo sapiens This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

negative regulation of transcription from RNA polymerase II promoter, regulation of action potential, placenta development, maternal placenta development, hair follicle development, reproductive developmental process,monosaccharide metabolic process, glucose metabolic process, generation of precursor metabolites and energy,transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,fatty acid metabolic process, fatty acid beta-oxidation, isoprenoid metabolic process, vitamin metabolic process, fat-soluble vitamin metabolic process, vitamin A metabolic process, lipid transport, cellular ion homeostasis, apoptosis, cell motion, cell adhesion, ensheathment of neurons, ectoderm development, female pregnancy, embryo implantation,steroid metabolic process, cholesterol metabolic process, cell death, cell proliferation, positive regulation of cell proliferation, negative regulation of cell proliferation, axon ensheathment, epidermis development, carbohydrate transport, hexose transport, fatty acid catabolic process, response to wounding, negative regulation of biosynthetic process, positive regulation of signal transduction, negative regulation of macromolecule biosynthetic process,negative regulation of macromolecule metabolic process, regulation of protein kinase cascade, negative regulation of gene expression, positive regulation of cell communication, positive regulation of protein kinase cascade, lipid localization, programmed cell death, regulation of phosphoinositide 3-kinase cascade, positive regulation of phosphoinositide 3-kinase cascade, monocarboxylic acid transport, monosaccharide transport, glucose transport,organic acid transport, fatty acid transport, lipid catabolic process, organic acid catabolic process, sterol metabolic process, death, cell migration, negative regulation of transcription, transmission of nerve impulse, regulation of action potential in neuron, hexose metabolic process, fatty acid oxidation, cellular homeostasis, developmental maturation,molting cycle process, hair cycle process, biological adhesion, lipid modification, negative regulation of cellular biosynthetic process, cell-substrate adhesion, lipid oxidation, growth, wound healing, regulation of cell proliferation,molting cycle, regulation of membrane potential, homeostatic process, hair cycle, anagen, keratinocyte proliferation,cellular lipid catabolic process, regulation of transcription, positive regulation of cell differentiation, regulation of fat cell differentiation, positive regulation of fat cell differentiation, negative regulation of transcription, DNA-dependent,negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, carboxylic acid catabolic process, decidualization, carboxylic acid transport, developmental growth, hair follicle maturation, cell motility, chemical homeostasis, regulation of epithelial cell proliferation, negative regulation of epithelial cell proliferation, ion homeostasis, neurological system process, positive regulation of developmental process, negative regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, keratinocyte migration, localization of cell, cellular chemical homeostasis,

Nucleus.