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Catalog: YD0072
Size
Price
Status
Qty.
100μg
$280.00
3 weeks

0

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Main Information
Reactivity

Human

Applications

WB, SDS-PAGE

Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS
Source
E.coli
Purity
SDS-PAGE >90%
Storage
-20°C/6 month,-80°C for long storage
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Antigen&Target Information
Sequence:
Amino acid: 264-465, with his-MBP tag.
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Gene Name:
AKT3
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Protein Name:
Akt3 protein
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Other Name:
RAC-gamma serine/threonine-protein kinase ;
Protein kinase Akt-3 ;
Protein kinase B gamma ;
PKB gamma ;
RAC-PK-gamma ;
STK-2 ;
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Database Link:
Organism Gene ID SwissProt
Human 10000; Q9Y243;
Mouse Q9WUA6;
Background:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.,enzyme regulation:Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation.,function:IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation.,subunit:Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation.,tissue specificity:In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.,
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Function:
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
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Cellular Localization:
AKT3: Cytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation.
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Tissue Expression:
In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal Cellular Processes >> Cell growth and death >> Apoptosis Cellular Processes >> Cell growth and death >> Cellular senescence Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton Organismal Systems >> Immune system >> Platelet activation Organismal Systems >> Immune system >> Neutrophil extracellular trap formation Organismal Systems >> Immune system >> Toll-like receptor signaling pathway Organismal Systems >> Immune system >> T cell receptor signaling pathway Organismal Systems >> Immune system >> B cell receptor signaling pathway Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis Organismal Systems >> Immune system >> Chemokine signaling pathway Organismal Systems >> Endocrine system >> Insulin signaling pathway Organismal Systems >> Endocrine system >> Glucagon signaling pathway Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway Organismal Systems >> Endocrine system >> Estrogen signaling pathway Organismal Systems >> Endocrine system >> Prolactin signaling pathway Organismal Systems >> Endocrine system >> Relaxin signaling pathway Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes Organismal Systems >> Nervous system >> Cholinergic synapse Organismal Systems >> Nervous system >> Dopaminergic synapse Organismal Systems >> Nervous system >> Neurotrophin signaling pathway Organismal Systems >> Development and regeneration >> Osteoclast differentiation Organismal Systems >> Aging >> Longevity regulating pathway Organismal Systems >> Aging >> Longevity regulating pathway - multiple species Human Diseases >> Cancer: overview >> Pathways in cancer Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer Human Diseases >> Cancer: specific types >> Colorectal cancer Human Diseases >> Cancer: specific types >> Pancreatic cancer Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma Human Diseases >> Cancer: specific types >> Gastric cancer Human Diseases >> Cancer: specific types >> Glioma Human Diseases >> Cancer: specific types >> Acute myeloid leukemia Human Diseases >> Cancer: specific types >> Chronic myeloid leukemia Human Diseases >> Cancer: specific types >> Melanoma Human Diseases >> Cancer: specific types >> Renal cell carcinoma Human Diseases >> Cancer: specific types >> Prostate cancer Human Diseases >> Cancer: specific types >> Endometrial cancer Human Diseases >> Cancer: specific types >> Breast cancer Human Diseases >> Cancer: specific types >> Small cell lung cancer Human Diseases >> Cancer: specific types >> Non-small cell lung cancer Human Diseases >> Neurodegenerative disease >> Alzheimer disease Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia Environmental Information Processing >> Signal transduction >> MAPK signaling pathway Environmental Information Processing >> Signal transduction >> ErbB signaling pathway Environmental Information Processing >> Signal transduction >> Ras signaling pathway Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway Environmental Information Processing >> Signal transduction >> VEGF signaling pathway Environmental Information Processing >> Signal transduction >> Apelin signaling pathway Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway Environmental Information Processing >> Signal transduction >> TNF signaling pathway Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway Environmental Information Processing >> Signal transduction >> FoxO signaling pathway Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway Environmental Information Processing >> Signal transduction >> cAMP signaling pathway Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway Environmental Information Processing >> Signal transduction >> AMPK signaling pathway Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Catalog: YD0072
Size
Price
Status
Qty.
100μg
$280.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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