ERBB2

Receptor tyrosine-protein kinase erbB-2 ;
Metastatic lymph node gene 19 protein ;
MLN 19 ;
Proto-oncogene Neu ;
Proto-oncogene c-ErbB-2 ;
Tyrosine kinase-type cell surface receptor HER2 ;
p185erbB2 ;
CD antigen CD340 ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,disease:Defects in ERBB2 are associated with familial glioma of brain [MIM:137800]; also called glioblastoma multiforme. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas , glioblastoma multiforme , oligodendrogliomas , and ependymomas. ,disease:Defects in ERBB2 are associated with gastric cancer [MIM:137215]; also known as hereditary familial diffuse gastric cancer (HDGC) . ,disease:Defects in ERBB2 are associated with lung cancer [MIM:211980]; also called adenocarcinoma of lung. ,disease:Defects in ERBB2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease , which is a principal determinant of outcome. ,function:Essential component of a neuregulin-receptor complex , although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF , TGF-alpha and amphiregulin. ,online information:ERBB2 entry ,polymorphism:There are fours alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a frequency of 0.012. ,PTM:Ligand-binding increases phosphorylation on tyrosine residues. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Heterodimer with each of the other ERBB receptors (Potential) . Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248. Interacts with MUC1. Stimulation by heregulin (HRG) in breast cancer cell lines induces binding of MUC1 with gamma-catenin. ,

cell morphogenesis , cell morphogenesis involved in differentiation , regulation of action potential , liver development ,negative regulation of immune system process , regulation of leukocyte activation , negative regulation of leukocyte activation , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cellular ion homeostasis , cell motion , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , intracellular signaling cascade , protein kinase cascade , ensheathment of neurons , axonogenesis , axon guidance , peripheral nervous system development ,sensory organ development , heart development , muscle organ development , skeletal muscle tissue development ,neuromuscular junction development , motor axon guidance , cell proliferation , positive regulation of cell proliferation ,negative regulation of cell proliferation , axon ensheathment , response to wounding , response to endogenous stimulus , response to hormone stimulus , positive regulation of signal transduction , glial cell differentiation , response to organic substance , regulation of protein kinase cascade , positive regulation of cell communication , positive regulation of protein kinase cascade , regulation of cell death , phosphoinositide 3-kinase cascade , regulation of phosphoinositide 3-kinase cascade , positive regulation of phosphoinositide 3-kinase cascade , striated muscle tissue development , phosphorylation , peptidyl-tyrosine phosphorylation , peptidyl-tyrosine modification , regulation of phosphate metabolic process , transmission of nerve impulse , regulation of action potential in neuron , cellular homeostasis , second-messenger-mediated signaling , ovulation cycle process , gland morphogenesis , cell projection organization , regulation of cell adhesion , neuron differentiation , mammary gland development , neuron projection development , multicellular organism reproduction , response to progesterone stimulus , regulation of mononuclear cell proliferation , negative regulation of mononuclear cell proliferation , cellular component morphogenesis , cell part morphogenesis , regulation of T cell differentiation in the thymus , regulation of immature T cell proliferation , regulation of immature T cell proliferation in the thymus , negative regulation of immature T cell proliferation , negative regulation of immature T cell proliferation in the thymus , positive regulation of kinase activity , wound healing , gliogenesis ,regulation of cell proliferation , regulation of T cell proliferation , negative regulation of T cell proliferation , regulation of phosphorylation , regulation of membrane potential , response to drug , myelination , homeostatic process , muscle cell differentiation , ovulation cycle , regulation of apoptosis , extracellular structure organization , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity , regulation of MAPKKK cascade , positive regulation of MAPKKK cascade , regulation of kinase activity , tongue development , positive regulation of molecular function , regulation of T cell differentiation , regulation of lymphocyte differentiation , regulation of angiogenesis , positive regulation of cell adhesion , regulation of protein kinase activity , positive regulation of protein kinase activity , regulation of Ras protein signal transduction , positive regulation of Ras protein signal transduction ,protein amino acid autophosphorylation , phosphoinositide-mediated signaling , autonomic nervous system development , sympathetic nervous system development , rhythmic process , response to steroid hormone stimulus ,reproductive process in a multicellular organism , neuron development , cell morphogenesis involved in neuron differentiation , response to axon injury , gland development , skeletal muscle fiber development , muscle fiber development , tissue remodeling , neuron projection morphogenesis , cell projection morphogenesis , chemical homeostasis , regulation of lymphocyte proliferation , negative regulation of lymphocyte proliferation , regulation of epithelial cell proliferation , positive regulation of epithelial cell proliferation , ion homeostasis , synapse organization ,regulation of T cell activation , regulation of cell activation , negative regulation of cell activation , negative regulation of T cell activation , neurological system process , regulation of small GTPase mediated signal transduction , positive regulation of small GTPase mediated signal transduction , striated muscle cell differentiation , regulation of phosphorus metabolic process , regulation of lymphocyte activation , negative regulation of lymphocyte activation , regulation of transferase activity , positive regulation of transferase activity , muscle cell development , striated muscle cell development , cellular chemical homeostasis , mammary gland involution , estrous cycle phase , estrus , mammary gland morphogenesis , muscle tissue development , skeletal muscle organ development , negative regulation of cell death ,regulation of leukocyte proliferation , negative regulation of leukocyte proliferation ,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein. Early endosome . Cytoplasm , perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis , probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794) . .; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.