EZR

Ezrin

EZR ;
VIL2 ;
Ezrin ;
Cytovillin ;
Villin-2 ;
p81

developmental stage:Very strong staining is detected in the Purkinje cell layer and in part of the molecular layer of the infant brain compared to adult brain. ,function:Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells , required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6 , required for normal macropinocytosis. ,PTM:Phosphorylated by tyrosine-protein kinases. ,similarity:Contains 1 FERM domain. ,subcellular location:Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity) . Microvillar peripheral membrane protein (cytoplasmic side) . ,subunit:Interacts with MPP5 (By similarity) . Interacts with SLC9A3R1 and SCYL3/PACE1. Interacts with PLEKHG6. Interacts with NGX6. ,tissue specificity:Expressed in cerebral cortex , basal ganglia , hippocampus , hypophysis , and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level) . Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus , frontal cortex , thalamus , parahippocampal cortex , amygdala , insula , and corpus callosum. Not detected in neurons in most tissues studied. ,

cell morphogenesis , cytoskeleton organization , actin filament organization , cytoskeletal anchoring at plasma membrane , cell adhesion , leukocyte adhesion , establishment or maintenance of cell polarity , protein localization ,regulation of cell shape , cell-cell adhesion , membrane docking , regulation of cell morphogenesis , biological adhesion ,membrane to membrane docking , actin filament-based process , actin cytoskeleton organization , epithelial cell differentiation , maintenance of protein location in cell , cellular component morphogenesis , establishment or maintenance of apical/basal cell polarity , maintenance of protein location , actin filament bundle formation ,maintenance of location , maintenance of location in cell , epithelium development ,

Apical cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection . Cell projection , microvillus membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection , ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm , cell cortex . Cytoplasm , cytoskeleton . Cell projection , microvillus . Localization to the apical membrane of parietal cells depends on the interaction with PALS1. Localizes to cell extensions and peripheral processes of astrocytes (By similarity) . Microvillar peripheral membrane protein (cytoplasmic side) . .