Catalog: KA1077C
Size
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Qty.
96well
$470.00
2 weeks
0
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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eIF2α Rabbit pAb
YT1507
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Primary Antibodies
eIF2α (Phospho Ser51) Rabbit pAb
YP0093
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ELISA Kits
Total eIF2α Cell-Based Colorimetric ELISA Kit
KA3093C
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ELISA Kits
eIF2α (Phospho Ser51) Cell-Based Colorimetric ELISA Kit
KA1077C
More→
Antigen&Target Information
Gene Name:
EIF2S1
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Other Name:
Eukaryotic translation initiation factor 2 subunit 1 ;
Eukaryotic translation initiation factor 2 subunit alpha ;
eIF-2-alpha ;
eIF-2A ;
eIF-2alpha ;
Eukaryotic translation initiation factor 2 subunit alpha ;
eIF-2-alpha ;
eIF-2A ;
eIF-2alpha ;
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Database Link:
Background:
function:Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit , followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation , the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. ,PTM:Substrate for at least 4 kinases: EIF2AK3/PERK , GCN2 , HRI and PKR. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction , thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation. In case of infection by vaccinia virus or rotavirus A , eIF2S1 phosphorylation state is modulated. ,similarity:Belongs to the eIF-2-alpha family. ,similarity:Contains 1 S1 motif domain. ,subunit:Heterotrimer composed of an alpha , a beta and a gamma chain. Component of an EIF2 complex at least composed of CUGBP1 , CALR , CALR3 , EIF2S1 , EIF2S2 , HSP90B1 and HSPA5. ,
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Function:
translation , regulation of translation , regulation of translational initiation , protein amino acid phosphorylation ,phosphorus metabolic process , phosphate metabolic process , posttranscriptional regulation of gene expression ,phosphorylation , regulation of cellular protein metabolic process , cellular response to stress , regulation of translation in response to stress , regulation of translational initiation in response to stress , protein amino acid autophosphorylation ,
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Cellular Localization:
Cytoplasm , Stress granule . Colocalizes with NANOS3 in the stress granules. .
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Cellular Processes >> Cell growth and death >> Apoptosis
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Parkinson disease
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Prion disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
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Catalog: KA1077C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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