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Main Information
Reactivity
Human
Applications
WB, SDS-PAGE
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS
Source
E.coli
Purity
SDS-PAGE >90%
Storage
-20°C/6 month,-80°C for long storage
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Antigen&Target Information
Sequence:
Amino acid: 22-120, with his-MBP tag.
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Gene Name:
HSPA8 HSC70 HSP73 HSPA10
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Protein Name:
Heat shock cognate 71 kDa protein
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Other Name:
HSPA8 ;
HSC70 ;
HSP73 ;
HSPA10 ;
Heat shock cognate 71 kDa protein ;
Heat shock 70 kDa protein 8
HSC70 ;
HSP73 ;
HSPA10 ;
Heat shock cognate 71 kDa protein ;
Heat shock 70 kDa protein 8
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Background:
function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous.,
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Function:
protein folding, 'de novo' protein folding, post-Golgi vesicle-mediated transport, response to unfolded protein,response to organic substance, membrane organization, vesicle-mediated transport, intracellular transport, Golgi vesicle transport, 'de novo' posttranslational protein folding, chaperone mediated protein folding requiring cofactor,regulation of cell cycle, response to protein stimulus,
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Cellular Localization:
Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
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Tissue Expression:
Ubiquitous.
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Signaling Pathway
Organismal Systems >> Immune system >> Antigen processing and presentation Organismal Systems >> Endocrine system >> Estrogen signaling pathway Organismal Systems >> Aging >> Longevity regulating pathway - multiple species Human Diseases >> Neurodegenerative disease >> Prion disease Environmental Information Processing >> Signal transduction >> MAPK signaling pathway Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum
Catalog: YD0038
Size
Price
Status
Qty.
100μg
$280.00
3 weeks
0
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