CAMK4

Calcium/calmodulin-dependent protein kinase type IV ;
CaMK IV ;
CaM kinase-GR ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Activated by Ca (2+) /calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. Autophosphorylation of the N-terminus is required for full activation. In part , activity is independent on Ca (2+) /calmodulin and autophosphorylation of Ser-336 allows to switch to a Ca (2+) /calmodulin-independent state (By similarity) . Probably inactivated by serine/threonine protein phosphatase 2A. ,function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro , phosphorylates CREB1 , CREBBP , PRM2 , MEF2A , MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory. ,PTM:Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity) . Dephosphorylated by serine/threonine protein phosphatase 2A , probably on Thr-200. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix. ,subunit:Monomer (By similarity) . Interacts with serine/threonine protein phosphatase 2A catalytic subunit , PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca (2+) /calmodulin. ,tissue specificity:Expressed in epithelial ovarian cancer tissue. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , nucleocytoplasmic transport , cell-cell signaling , synaptic transmission , nerve-nerve synaptic transmission , phosphorylation , transmission of nerve impulse , intracellular transport , neurological system process , nuclear transport ,

Cytoplasm. Nucleus. Localized in hippocampal neuron nuclei. In spermatids , associated with chromatin and nuclear matrix (By similarity) . .