Catalog: KA1044C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Primary Antibodies
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ELISA Kits
CaMKIIα/δ (Phospho Thr286) Cell-Based Colorimetric ELISA Kit
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Antigen&Target Information
Gene Name:
CAMK2A/CAMK2D
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Database Link:
Background:
catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. ,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Postsynaptic lipid rafts. ,subunit:CAMK2 is composed of four different chains: alpha , beta , gamma , and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC , MPDZ , SYN1 , CAMK2N2 and SYNGAP1. ,
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Function:
G1/S transition of mitotic cell cycle , mitotic cell cycle , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , ion transport , cation transport , calcium ion transport , cell cycle , di- , tri-valent inorganic cation transport , phosphorylation , cell cycle process , cell cycle phase , metal ion transport , regulation of neurological system process , positive regulation of DNA binding , regulation of system process , positive regulation of molecular function , regulation of transcription , protein amino acid autophosphorylation , regulation of neurotransmitter secretion , regulation of synaptic plasticity , regulation of neuronal synaptic plasticity , regulation of synaptic transmission , regulation of secretion , regulation of transcription factor activity , positive regulation of transcription factor activity , positive regulation of NF-kappaB transcription factor activity , regulation of binding , positive regulation of binding , regulation of DNA binding , interphase , interphase of mitotic cell cycle , regulation of neurotransmitter transport , regulation of transmission of nerve impulse , regulation of cellular localization ,
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Cellular Localization:
Cell junction , synapse . Cell junction , synapse , postsynaptic density . Cell projection , dendritic spine . Cell projection , dendrite . Postsynaptic lipid rafts. .
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Endocrine system >> Insulin secretion
Organismal Systems >> Endocrine system >> Glucagon signaling pathway
Organismal Systems >> Endocrine system >> GnRH signaling pathway
Organismal Systems >> Endocrine system >> Oxytocin signaling pathway
Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion
Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes
Organismal Systems >> Nervous system >> Cholinergic synapse
Organismal Systems >> Nervous system >> Dopaminergic synapse
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: specific types >> Glioma
Human Diseases >> Neurodegenerative disease >> Parkinson disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> ErbB signaling pathway
Environmental Information Processing >> Signal transduction >> Wnt signaling pathway
Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
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Catalog: KA1044C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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