function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.,similarity:Belongs to the protease inhibitor I35 (TIMP) family.,similarity:Contains 1 NTR domain.,tissue specificity:Abundant in heart and present at low levels in many other tissues.,
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Function:
response to molecule of bacterial origin, response to bacterium, response to endogenous stimulus, response to hormone stimulus, response to organic substance, response to lipopolysaccharide, multicellular organism reproduction, response to cytokine stimulus, response to drug, ovulation cycle, response to peptide hormone stimulus, rhythmic process, reproductive process in a multicellular organism,
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Cellular Localization:
Secreted.
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Tissue Expression:
Abundant in heart and present at low levels in many other tissues.