RIPK2

Receptor-interacting serine/threonine-protein kinase 2 ;
CARD-containing interleukin-1 beta-converting enzyme-associated kinase ;
CARD-containing IL-1 beta ICE-kinase ;
RIP-like-interacting CLARP kinase ;
Receptor-interacting protein 2 ;
RIP-2 ;
Tyrosine-protein kinase RIPK2 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex.,tissue specificity:Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.,

cell activation, regulation of cytokine production, positive regulation of cytokine production, activation of innate immune response, pattern recognition receptor signaling pathway, toll-like receptor signaling pathway, response to molecule of bacterial origin, activation of immune response, immune response-activating cell surface receptor signaling pathway, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, immune response-activating signal transduction, innate immune response-activating signal transduction, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process,apoptosis, anti-apoptosis, defense response, inflammatory response, cell surface receptor linked signal transduction,cell death, cell proliferation, positive regulation of cell proliferation, response to wounding, response to bacterium,positive regulation of signal transduction, response to organic substance, regulation of protein kinase cascade,positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death,positive regulation of cell death, programmed cell death, death, phosphorylation, positive regulation of defense response, lipopolysaccharide-mediated signaling pathway, response to peptidoglycan, response to lipopolysaccharide,regulation of chemokine production, regulation of interferon-gamma production, regulation of interleukin-2 production,regulation of interleukin-6 production, regulation of tumor necrosis factor production, positive regulation of chemokine production, positive regulation of interferon-gamma production, positive regulation of interleukin-2 production, positive regulation of interleukin-6 production, positive regulation of tumor necrosis factor production, regulation of stress-activated MAPK cascade, positive regulation of stress-activated MAPK cascade, mononuclear cell proliferation,regulation of mononuclear cell proliferation, positive regulation of mononuclear cell proliferation, regulation of immature T cell proliferation, positive regulation of immature T cell proliferation, response to cytokine stimulus, toll-like receptor 2 signaling pathway, toll-like receptor 4 signaling pathway, T cell proliferation, positive regulation of T cell proliferation, T cell activation, regulation of cell proliferation, regulation of T cell proliferation, defense response to bacterium, regulation of apoptosis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death,regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of I-kappaB kinase/NF-kappaB cascade,response to exogenous dsRNA, response to dsRNA, positive regulation of DNA binding, regulation of MAPKKK cascade,positive regulation of MAPKKK cascade, positive regulation of molecular function, regulation of innate immune response, positive regulation of innate immune response, leukocyte activation, regulation of transcription, regulation of JNK cascade, positive regulation of JNK cascade, regulation of alpha-beta T cell activation, positive regulation of alpha-beta T cell activation, regulation of alpha-beta T cell proliferation, positive regulation of alpha-beta T cell proliferation, lymphocyte activation, lymphocyte proliferation, positive regulation of response to stimulus, regulation of lymphocyte proliferation, positive regulation of lymphocyte proliferation, positive regulation of immune response,defense response to Gram-positive bacterium, antigen receptor-mediated signaling pathway, T cell receptor signaling pathway, regulation of T cell activation, regulation of cell activation, positive regulation of cell activation, positive regulation of T cell activation, regulation of transcription factor activity, positive regulation of transcription factor activity, positive regulation of NF-kappaB transcription factor activity, regulation of binding, positive regulation of binding, regulation of DNA binding, positive regulation of multicellular organismal process, regulation of lymphocyte activation, positive regulation of lymphocyte activation, negative regulation of cell death, regulation of stress-activated protein kinase signaling pathway, positive regulation of stress-activated protein kinase signaling pathway, regulation of ERK1 and ERK2 cascade, positive regulation of ERK1 and ERK2 cascade, response to lipoteichoic acid, nucleotide-binding oligomerization domain containing signaling pathway, nucleotide-binding oligomerization domain containing 1 signaling pathway, nucleotide-binding oligomerization domain containing 2 signaling pathway, response to interleukin-1, leukocyte proliferation, regulation of leukocyte proliferation, positive regulation of leukocyte proliferation, regulation of cellular response to stress,

Cytoplasm .

Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.