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Total p56 Dok-2 Cell-Based Colorimetric ELISA Kit

-KA4211C

Catalog: KA4211C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Dok-2 (Phospho Tyr299) Rabbit pAb
YP0085

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ELISA Kits
Total p56 Dok-2 Cell-Based Colorimetric ELISA Kit
KA4211C

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Antigen&Target Information
Gene Name:
DOK2
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Other Name:
Docking protein 2 ;
Downstream of tyrosine kinase 2 ;
p56 ;
dok-2 ;
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Database Link:
Organism Gene ID SwissProt
Human 9046; O60496;
Mouse O70469;
Background:
domain:PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.,PTM:On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP.,similarity:Belongs to the DOK family. Type A subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK.,tissue specificity:Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.,
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Function:
cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, intracellular signaling cascade, small GTPase mediated signal transduction, Ras protein signal transduction,
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Tissue Expression:
Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
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Catalog: KA4211C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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