NCF1

Neutrophil cytosol factor 1 ;
NCF-1 ;
47 kDa autosomal chronic granulomatous disease protein ;
47 kDa neutrophil oxidase factor ;
NCF-47K ;
Neutrophil NADPH oxidase factor 1 ;
Nox organizer 2 ;
Nox-organizing protein 2 ;
SH3 and PX domain-containing protein 1A ;
p47-phox ;

disease:Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:233700]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,function:NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).,online information:NCF1 deficiency database,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with NOXA1.,

oxygen and reactive oxygen species metabolic process, superoxide metabolic process, defense response, immune response, cellular defense response, superoxide anion generation, innate immune response, respiratory burst,

Cytoplasm, cytosol . Membrane ; Peripheral membrane protein ; Cytoplasmic side .

Detected in peripheral blood monocytes and neutrophils (at protein level).