MAP2K7

Dual specificity mitogen-activated protein kinase kinase 7 ;
MAP kinase kinase 7 ;
MAPKK 7 ;
JNK-activating kinase 2 ;
MAPK/ERK kinase 7 ;
MEK 7 ;
Stress-activated protein kinase kinase 4 ;
SAPK kinase 4 ;
SAPKK-4 ;
SAPKK4 ;
c-Jun N-terminal kinase kinase 2 ;
JNK kinase 2 ;
JNKK 2 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.,function:Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.,PTM:Activated by phosphorylation on Ser/Thr.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.,

MAPKKK cascade, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process,intracellular signaling cascade, protein kinase cascade, phosphorylation, stress-activated protein kinase signaling pathway, cellular response to stress, stress-activated MAPK cascade,

Nucleus. Cytoplasm .

Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.