LIPE

Hormone-sensitive lipase ;
HSL ;

catalytic activity:Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate.,catalytic activity:Monoacylglycerol + H(2)O = glycerol + a carboxylate.,catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,enzyme regulation:Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.,function:In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.,pathway:Glycerolipid metabolism; triacylglycerol degradation.,similarity:Belongs to the 'GDXG' lipolytic enzyme family.,subcellular location:Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.,subunit:Interacts with PTRF in the adipocyte cytoplasm.,

protein amino acid phosphorylation, neutral lipid metabolic process, acylglycerol metabolic process, triglyceride metabolic process, glycerol ether metabolic process, phosphorus metabolic process, phosphate metabolic process,female pregnancy, steroid metabolic process, cholesterol metabolic process, lipid catabolic process, sterol metabolic process, phosphorylation, organic ether metabolic process, triglyceride catabolic process, response to drug, cellular lipid catabolic process, glycerol ether catabolic process, diacylglycerol metabolic process, diacylglycerol catabolic process, neutral lipid catabolic process, acylglycerol catabolic process, glycerolipid metabolic process, glycerolipid catabolic process,

Cell membrane . Membrane, caveola . Cytoplasm, cytosol . Lipid droplet . Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Phosphorylation by AMPK reduces its translocation towards the lipid droplets (By similarity). .

Testis.