Contact Us

408-747-0189
1-877-594-3616

Quick order

Total GSK3β Cell-Based Colorimetric ELISA Kit

-KA4112C

Catalog: KA4112C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service
Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
Related Products
Primary Antibodies
GSK3β Rabbit pAb
YT2082

More→

Primary Antibodies
GSK3β (Phospho Ser9) Rabbit pAb
YP0285

More→

Primary Antibodies
GSK3β (Phospho Ser9) Rabbit pAb
YP0124

More→

Primary Antibodies
GSK3β (PTR2553) Mouse mAb
YM3633

More→

ELISA Kits
Total GSK3β Cell-Based Colorimetric ELISA Kit
KA4112C

More→

ELISA Kits
GSK3β (Phospho Ser9) Cell-Based Colorimetric ELISA Kit
KA1578C

More→

Antigen&Target Information
Gene Name:
GSK3B
show all
Other Name:
Glycogen synthase kinase-3 beta ;
GSK-3 beta ;
Serine/threonine-protein kinase GSK3B ;
show all
Database Link:
Organism Gene ID SwissProt
Human 2932; P49841;
Mouse Q9WV60;
Rat P18266;
Background:
catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.,
show all
Function:
re-entry into mitotic cell cycle, polysaccharide metabolic process, glycogen metabolic process, monosaccharide metabolic process, glucose metabolic process, cellular glucan metabolic process, generation of precursor metabolites and energy, energy reserve metabolic process, protein amino acid phosphorylation, protein targeting, protein export from nucleus, phosphorus metabolic process, phosphate metabolic process, intracellular protein transport,nucleocytoplasmic transport, anti-apoptosis, ER overload response, ER-nuclear signaling pathway, cell cycle, cell surface receptor linked signal transduction, intracellular signaling cascade, protein localization, regulation of cell death,protein transport, energy derivation by oxidation of organic compounds, Wnt receptor signaling pathway,phosphorylation, peptidyl-serine phosphorylation, peptidyl-serine modification, hexose metabolic process, cell cycle process, positive regulation of protein complex assembly, regulation of intracellular transport, positive regulation of intracellular transport, regulation of protein localization, regulation of intracellular protein transport, cellular response to stress, cellular protein localization, response to endoplasmic reticulum stress, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death,regulation of protein complex assembly, glucan metabolic process, regulation of cellular component biogenesis, cellular polysaccharide metabolic process, establishment of protein localization, fat cell differentiation, regulation of nucleocytoplasmic transport, positive regulation of nucleocytoplasmic transport, regulation of protein export from nucleus, positive regulation of protein export from nucleus, intracellular transport, positive regulation of transport,positive regulation of cellular component organization, nuclear export, nuclear transport, positive regulation of protein transport, regulation of protein transport, Wnt receptor signaling pathway through beta-catenin, regulation of cellular localization, negative regulation of cell death, regulation of establishment of protein localization, cellular macromolecule localization,
show all
Cellular Localization:
Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .
show all
Tissue Expression:
Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.
show all
Signaling Pathway
Cellular Processes >> Cell growth and death >> Cell cycle Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells Organismal Systems >> Immune system >> T cell receptor signaling pathway Organismal Systems >> Immune system >> IL-17 signaling pathway Organismal Systems >> Immune system >> B cell receptor signaling pathway Organismal Systems >> Immune system >> Chemokine signaling pathway Organismal Systems >> Endocrine system >> Insulin signaling pathway Organismal Systems >> Endocrine system >> Prolactin signaling pathway Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway Organismal Systems >> Nervous system >> Dopaminergic synapse Organismal Systems >> Nervous system >> Neurotrophin signaling pathway Human Diseases >> Cancer: overview >> Pathways in cancer Human Diseases >> Cancer: specific types >> Colorectal cancer Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma Human Diseases >> Cancer: specific types >> Gastric cancer Human Diseases >> Cancer: specific types >> Basal cell carcinoma Human Diseases >> Cancer: specific types >> Prostate cancer Human Diseases >> Cancer: specific types >> Endometrial cancer Human Diseases >> Cancer: specific types >> Breast cancer Human Diseases >> Neurodegenerative disease >> Alzheimer disease Human Diseases >> Neurodegenerative disease >> Prion disease Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases Environmental Information Processing >> Signal transduction >> ErbB signaling pathway Environmental Information Processing >> Signal transduction >> Wnt signaling pathway Environmental Information Processing >> Signal transduction >> Hedgehog signaling pathway Environmental Information Processing >> Signal transduction >> Hippo signaling pathway Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Catalog: KA4112C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

Toggle night Mode

{{pinfoXq.title || ''}}

Catalog: {{pinfoXq.catalog || ''}}
Filter:

All

{{item.name}}

{{pinfo.title}}
-{{pinfo.catalog}}

Filter:

{{item.descr}}

Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Learn more
Product {{index}}/{{pcount}}
Prev
Next

{{pvTitle}}

Scroll wheel zooms the picture
{{pvDescr}}