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Total Collagen V α1 Cell-Based Colorimetric ELISA Kit

-KA4047C

Catalog: KA4047C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Total Collagen V α1 Cell-Based Colorimetric ELISA Kit
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Antigen&Target Information
Gene Name:
COL5A1
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Other Name:
Collagen alpha-1 ;
V ;
chain
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Database Link:
Organism Gene ID SwissProt
Human 1289; P20908;
Mouse O88207;
Background:
disease:Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome.,disease:Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 2 (EDS2) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome.,function:Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,PTM:Sulfated on 40% of tyrosines.,similarity:Belongs to the fibrillar collagen family.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,subunit:Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.,
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Function:
blood vessel development, eye development, vasculature development, heart morphogenesis, cell motion, plasma membrane organization, cell adhesion, ectoderm development, sensory organ development, heart development,epidermis development, response to wounding, membrane organization, cell migration, biological adhesion,extracellular matrix organization, collagen fibril organization, collagen metabolic process, collagen biosynthetic process, wound healing, spreading of epidermal cells, wound healing, extracellular structure organization, fibril organization, skin development, multicellular organismal metabolic process, multicellular organismal macromolecule metabolic process, integrin biosynthetic process, eye morphogenesis, cell motility, localization of cell,
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Cellular Localization:
Secreted, extracellular space, extracellular matrix .
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Catalog: KA4047C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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