CDK5

Cyclin-dependent kinase 5 ;
Cell division protein kinase 5 ;
Serine/threonine-protein kinase PSSALRE ;
Tau protein kinase II catalytic subunit ;
TPKII catalytic subunit ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:In axonal growth cone with extension to the peripheral lamellipodia.,subunit:Heterodimer of a catalytic subunit and a regulatory subunit (p35). Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 (By similarity). Interacts with AATK.,

cell morphogenesis, cell morphogenesis involved in differentiation, neuron migration, synaptic transmission, dopaminergic, protein complex assembly, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, cellular ion homeostasis, intracellular protein transport, exocytosis, endocytosis,apoptosis, cell motion, cytoskeleton organization, cell cycle, cell adhesion, cell-matrix adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, signal complex assembly, intracellular signaling cascade, protein kinase cascade,JAK-STAT cascade, cell-cell signaling, synaptic transmission, nerve-nerve synaptic transmission, axonogenesis, axon guidance, peripheral nervous system development, muscle organ development, skeletal muscle tissue development,sensory perception, behavior, learning or memory, learning, visual behavior, motor axon guidance, protein localization,cell death, cell proliferation, associative learning, visual learning, macromolecule catabolic process, response to radiation, response to light stimulus, response to wounding, response to abiotic stimulus, glial cell differentiation,response to organic substance, membrane invagination, negative regulation of macromolecule metabolic process,regulation of cell death, positive regulation of cell death, programmed cell death, Schwann cell differentiation,Schwann cell development, response to organic cyclic substance, response to tropane, striated muscle tissue development, protein transport, membrane organization, vesicle-mediated transport, death, phosphorylation,dendrite development, cell migration, regulation of exocytosis, regulation of calcium ion-dependent exocytosis,peptidyl-serine phosphorylation, peptidyl-serine modification, regulation of phosphate metabolic process, transmission of nerve impulse, sensory perception of pain, cellular homeostasis, telencephalon development, pallium development,cerebellum development, hindbrain morphogenesis, cerebellum morphogenesis, cerebellar cortex development,cerebellar cortex morphogenesis, cerebellar cortex formation, limbic system development, hippocampus development,glial cell development, cerebral cortex cell migration, cerebral cortex radially oriented cell migration, cerebral cortex radial glia guided migration, layer formation in the cerebral cortex, forebrain cell migration, central nervous system neuron differentiation, central nervous system neuron development, cerebral cortex development, telencephalon cell migration, metencephalon development, corpus callosum development, biological adhesion, actin filament-based process, cell projection organization, actin cytoskeleton organization, neuron differentiation, regulation of cell migration, adult behavior, cortical cytoskeleton organization, cortical actin cytoskeleton organization, forebrain development, hindbrain development, neuron projection development, regulation of protein ubiquitination, negative regulation of protein ubiquitination, regulation of protein modification process, negative regulation of protein modification process, cell-substrate adhesion, regulation of neurological system process, negative regulation of synaptic plasticity, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, regulation of intracellular transport, negative regulation of intracellular transport, receptor catabolic process,regulation of protein localization, secretion by cell, cellular component morphogenesis, cell part morphogenesis, serine phosphorylation of STAT3 protein, regulation of intracellular protein transport, positive regulation of kinase activity,cellular protein localization, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, synaptic transmission, glutamatergic, regulation of locomotion, gliogenesis, response to cocaine, regulation of phosphorylation, regulation of membrane potential, serine phosphorylation of STAT protein, homeostatic process,regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of catalytic activity, receptor metabolic process, receptor clustering,response to alkaloid, regulation of neuron apoptosis, positive regulation of neuron apoptosis, regulation of kinase activity, cellular protein complex assembly, macromolecular complex subunit organization, regulation of system process, positive regulation of molecular function, regulated secretory pathway, establishment of protein localization,negative regulation of cell cycle, regulation of protein kinase activity, positive regulation of protein kinase activity,positive regulation of exocytosis, positive regulation of calcium ion-dependent exocytosis, protein amino acid autophosphorylation, regulation of nucleocytoplasmic transport, negative regulation of nucleocytoplasmic transport,regulation of protein export from nucleus, negative regulation of protein export from nucleus, secretion, intracellular transport, behavioral response to cocaine, regulation of synaptic plasticity, synaptic vesicle endocytosis, synaptic vesicle transport, neuron development, cell morphogenesis involved in neuron differentiation, neuron projection morphogenesis, dendrite morphogenesis, cell projection morphogenesis, cell motility, chemical homeostasis, ion homeostasis, regulation of synaptic transmission, neurological system process, cognition, regulation of secretion,positive regulation of secretion, positive regulation of transport, negative regulation of transport, regulation of phosphorus metabolic process, regulation of protein transport, negative regulation of protein transport, negative regulation of protein metabolic process, regulation of cell motion, cell division, regulation of transferase activity,positive regulation of transferase activity, neuron apoptosis, localization of cell, regulation of cell cycle, membrane depolarization, regulation of transmission of nerve impulse, cellular chemical homeostasis, regulation of postsynaptic membrane potential, regulation of excitatory postsynaptic membrane potential, regulation of cellular localization,muscle tissue development, skeletal muscle organ development, regulation of vesicle-mediated transport,macromolecular complex assembly, regulation of establishment of protein localization, protein complex biogenesis,cellular macromolecule localization,

[Isoform 1]: Cytoplasm . Nucleus . Cell membrane ; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium . Cell projection, growth cone . Cell junction, synapse, postsynaptic density . Cell junction, synapse . In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5. .; [Isoform 2]: Nucleus.

[Isoform 1]: Ubiquitously expressed (PubMed:17009320, PubMed:19693690). Accumulates in cortical neurons (at protein level) (PubMed:17009320). ; [Isoform 2]: Expressed in the testis, skeletal muscle, colon, bone marrow and ovary.