CBL

E3 ubiquitin-protein ligase CBL ;
Casitas B-lineage lymphoma proto-oncogene ;
Proto-oncogene c-Cbl ;
RING finger protein 55 ;
Signal transduction protein CBL ;

disease:Can be converted to an oncogenic protein by deletions or mutations that disturb its ability to down-regulate RTKs.,domain:The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.,domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.,function:Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.,miscellaneous:This protein has one functional calcium-binding site.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated on tyrosine residues by EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine residues by INSR.,similarity:Contains 1 CBL N-terminal domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 UBA domain.,similarity:Contains 2 EF-hand-like domains.,subunit:Associates with NCK via its SH3 domain. The phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with adapters SLA, SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR, SYK and ZAP70 via the highly conserved Cbl-N region. Also interacts with SORBS1 and INPPL1/SHIP2. Interacts with phosphorylated LAT2. May interact with CBLB.,

proteolysis, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway,transmembrane receptor protein tyrosine kinase signaling pathway, epidermal growth factor receptor signaling pathway, macromolecule catabolic process, protein ubiquitination, modification-dependent protein catabolic process,regulation of endocytosis, protein catabolic process, protein modification by small protein conjugation, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, positive regulation of endocytosis, regulation of receptor-mediated endocytosis, positive regulation of receptor-mediated endocytosis, positive regulation of transport, positive regulation of cellular component organization, proteolysis involved in cellular protein catabolic process, regulation of vesicle-mediated transport,protein modification by small protein conjugation or removal,

Cytoplasm. Cell membrane. Cell projection, cilium . Golgi apparatus . Colocalizes with FGFR2 in lipid rafts at the cell membrane.