BCL6

B-cell lymphoma 6 protein ;
BCL-6 ;
B-cell lymphoma 5 protein ;
BCL-5 ;
Protein LAZ-3 ;
Zinc finger and BTB domain-containing protein 27 ;
Zinc finger protein 51 ;

disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.,disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.,disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.,function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.,induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan.,PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.,tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.,

regulation of DNA recombination, protein import into nucleus, translocation, negative regulation of transcription from RNA polymerase II promoter, cell morphogenesis, regulation of cell growth, cell activation, regulation of cytokine production, negative regulation of cytokine production, regulation of cell-matrix adhesion, negative regulation of cell-matrix adhesion, immune system development, leukocyte differentiation, regulation of germinal center formation,regulation of immunoglobulin production, negative regulation of immune system process, positive regulation of immune system process, regulation of leukocyte activation, negative regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of immune effector process, negative regulation of immune effector process, regulation of production of molecular mediator of immune response, negative regulation of production of molecular mediator of immune response, regulation of leukocyte mediated immunity, regulation of lymphocyte mediated immunity, regulation of B cell mediated immunity, regulation of cytokine production during immune response,negative regulation of cytokine production during immune response, regulation of adaptive immune response,negative regulation of adaptive immune response, regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, regulation of T-helper 2 type immune response, negative regulation of T-helper 2 type immune response,regulation of immunoglobulin mediated immune response, regulation of B cell apoptosis, negative regulation of B cell apoptosis, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein targeting, protein import into nucleus, intracellular protein transport, nucleocytoplasmic transport,response to DNA damage stimulus, cytoskeleton organization, regulation of S phase of mitotic cell cycle, negative regulation of cell adhesion, gamete generation, spermatogenesis, regulation of mitotic cell cycle, protein localization,positive regulation of cell proliferation, negative regulation of cell proliferation, regulation of cell size, negative regulation of biosynthetic process, negative regulation of signal transduction, negative regulation of macromolecule biosynthetic process, regulation of cell cycle process, negative regulation of macromolecule metabolic process,negative regulation of gene expression, negative regulation of cell communication, regulation of cell-substrate adhesion, negative regulation of cell-substrate adhesion, regulation of cell death, positive regulation of cell death,negative regulation of cell cycle process, protein transport, negative regulation of transcription, protein import, sexual reproduction, actin filament-based process, actin cytoskeleton organization, hemopoiesis, lymphocyte differentiation,myeloid cell differentiation, regulation of cell adhesion, B cell differentiation, erythrocyte differentiation, negative regulation of cell growth, regulation of B cell proliferation, positive regulation of B cell proliferation, negative regulation of cellular biosynthetic process, regulation of response to external stimulus, regulation of Ras GTPase activity,regulation of Rho GTPase activity, multicellular organism reproduction, regulation of cellular component size, regulation of mast cell cytokine production, negative regulation of mast cell cytokine production, regulation of mononuclear cell proliferation, positive regulation of mononuclear cell proliferation, cellular component morphogenesis, regulation of S phase, protein localization in organelle, cellular response to stress, erythrocyte homeostasis, protein localization in nucleus, cellular protein localization, regulation of Rho protein signal transduction, negative regulation of Rho protein signal transduction, regulation of growth, B cell activation, regulation of cell proliferation, homeostatic process,regulation of apoptosis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death, regulation of GTPase activity, regulation of CD4-positive, alpha beta T cell differentiation, negative regulation of CD4-positive, alpha beta T cell differentiation, regulation of memory T cell differentiation, establishment of protein localization, regulation of isotype switching, leukocyte activation, regulation of transcription, regulation of T cell differentiation, negative regulation of T cell differentiation, negative regulation of cell differentiation, regulation of lymphocyte differentiation,negative regulation of lymphocyte differentiation, regulation of T-helper cell differentiation, negative regulation of T-helper cell differentiation, regulation of T-helper 2 cell differentiation, negative regulation of T-helper 2 cell differentiation, negative regulation of S phase of mitotic cell cycle, negative regulation of cell cycle, negative regulation of cell size, negative regulation of isotype switching, negative regulation of transcription, DNA-dependent, negative regulation of DNA recombination, negative regulation of growth, negative regulation of mitotic cell cycle, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of Ras protein signal transduction, negative regulation of Ras protein signal transduction, regulation of alpha-beta T cell activation,negative regulation of alpha-beta T cell activation, regulation of alpha-beta T cell differentiation, negative regulation of alpha-beta T cell differentiation, lymphocyte activation, intracellular transport, male gamete generation, regulation of isotype switching to IgE isotypes, negative regulation of isotype switching to IgE isotypes, hemopoietic or lymphoid organ development, negative regulation of response to stimulus, reproductive process in a multicellular organism,erythrocyte development, homeostasis of number of cells, regulation of lymphocyte proliferation, positive regulation of lymphocyte proliferation, regulation of inflammatory response, negative regulation of immune response, regulation of T cell activation, regulation of B cell activation, regulation of cell activation, negative regulation of cell activation,positive regulation of cell activation, negative regulation of T cell activation, negative regulation of B cell activation,positive regulation of B cell activation, regulation of DNA metabolic process, negative regulation of DNA metabolic process, regulation of small GTPase mediated signal transduction, negative regulation of small GTPase mediated signal transduction, nuclear transport, nuclear import, negative regulation of nitrogen compound metabolic process,negative regulation of multicellular organismal process, regulation of lymphocyte activation, negative regulation of lymphocyte activation, positive regulation of lymphocyte activation, regulation of RNA metabolic process, negative regulation of RNA metabolic process, regulation of cell motion, positive regulation of cell motion, regulation of hydrolase activity, regulation of cell cycle, negative regulation of cell death, regulation of lymphocyte apoptosis,negative regulation of lymphocyte apoptosis, regulation of leukocyte proliferation, positive regulation of leukocyte proliferation, cellular macromolecule localization,

Nucleus .

Expressed in germinal center T- and B-cells and in primary immature dendritic cells.