ADD1/ADD2

alternative products:Additional isoforms seem to exist,domain:Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.,function:Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.,PTM:The N-terminus is blocked.,similarity:Belongs to the aldolase class II family. Adducin subfamily.,subunit:Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Binds ROCK1.,tissue specificity:Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.,

cell morphogenesis, in utero embryonic development, tissue homeostasis, immune system development, cell volume homeostasis, cytoskeleton organization, actin filament organization, regulation of actin polymerization or depolymerization, embryonic development ending in birth or egg hatching, negative regulation of organelle organization, cellular homeostasis, hemoglobin metabolic process, actin filament-based process, actin cytoskeleton organization, hemopoiesis, myeloid cell differentiation, erythrocyte differentiation, regulation of actin filament length,regulation of actin filament polymerization, regulation of actin filament depolymerization, negative regulation of actin filament depolymerization, negative regulation of actin filament polymerization, negative regulation of protein complex assembly, positive regulation of protein binding, regulation of protein polymerization, negative regulation of protein polymerization, regulation of cellular component size, regulation of actin cytoskeleton organization, regulation of actin filament-based process, cellular component morphogenesis, regulation of organelle organization, erythrocyte homeostasis, multicellular organism growth, growth, homeostatic process, chordate embryonic development, negative regulation of protein complex disassembly, regulation of protein complex disassembly, regulation of protein complex assembly, regulation of protein binding, regulation of cellular component biogenesis, positive regulation of molecular function, hemopoietic or lymphoid organ development, multicellular organismal homeostasis, homeostasis of number of cells, homeostasis of number of cells within a tissue, barbed-end actin filament capping, actin filament bundle formation, regulation of binding, positive regulation of binding, negative regulation of cellular component organization,regulation of cytoskeleton organization, negative regulation of cytoskeleton organization, actin filament capping,anatomical structure homeostasis,

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.