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Cleaved SUMO-2/3 (Gly93) Cell-Based Colorimetric ELISA Kit

-KA3976C

Catalog: KA3976C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
SUMO2
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Other Name:
Small ubiquitin-related modifier 2 ;
SUMO-2 ;
HSMT3 ;
SMT3 homolog 2 ;
SUMO-3 ;
Sentrin-2 ;
Ubiquitin-like protein SMT3A ;
Smt3A ;
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Database Link:
Organism Gene ID SwissProt
Human 6613; P61956;
Mouse P61957;
Rat P61959;
Background:
function:Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.,online information:SUMO protein entry,PTM:Cleavage of precursor form by SENP1 or SENP2 is necessary for function.,PTM:Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.,PTM:Polymeric chains can be formed through Lys-11 cross-linking.,similarity:Belongs to the ubiquitin family. SUMO subfamily.,similarity:Contains 1 ubiquitin-like domain.,subcellular location:Nuclear bodies.,subunit:Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1.,subunit:Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins.,tissue specificity:Broadly expressed.,tissue specificity:Expressed predominantly in liver.,
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Function:
proteolysis, macromolecule catabolic process, protein sumoylation, modification-dependent protein catabolic process,protein catabolic process, protein modification by small protein conjugation, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, proteolysis involved in cellular protein catabolic process, protein modification by small protein conjugation or removal,
show all
Cellular Localization:
Nucleus. Nucleus, PML body.
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Tissue Expression:
Broadly expressed.
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Catalog: KA3976C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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