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Cleaved PARP-1 (Gly215) Cell-Based Colorimetric ELISA Kit

-KA3972C

Catalog: KA3972C
Size
Price
Status
Qty.
96well
$330.00
In stock

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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
PARP1
show all
Other Name:
Poly [ADP-ribose] polymerase 1 ;
PARP-1 ;
ADP-ribosyltransferase diphtheria toxin-like 1 ;
ARTD1 ;
NAD ;
+ ;
ADP-ribosyltransferase 1 ;
ADPRT 1 ;
Poly[ADP-ribose] synthase 1 ;
show all
Database Link:
Organism Gene ID SwissProt
Human 142; P09874;
Mouse P11103;
Background:
catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.,miscellaneous:The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.,PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Poly-ADP-ribosylated by PARP2.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 2 PARP-type zinc fingers.,subunit:Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423.,
show all
Function:
telomere maintenance, DNA metabolic process, DNA repair, base-excision repair, transcription, transcription, DNA-dependent, transcription from RNA polymerase II promoter, protein amino acid ADP-ribosylation, response to DNA damage stimulus, response to endogenous stimulus, response to hormone stimulus, response to organic substance,protein processing, protein autoprocessing, telomere organization, RNA biosynthetic process, response to insulin stimulus, cellular response to insulin stimulus, cellular response to hormone stimulus, cellular response to stress,regulation of growth, regulation of growth rate, homeostatic process, DNA damage response, detection of DNA damage, response to peptide hormone stimulus, chromosome organization, protein maturation, detection of stimulus,anatomical structure homeostasis,
show all
Cellular Localization:
Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .
show all
Catalog: KA3972C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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