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Cleaved MMP-12 (Gly106) Cell-Based Colorimetric ELISA Kit

-KA3966C

Catalog: KA3966C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Cleaved MMP-12 (Gly106) Cell-Based Colorimetric ELISA Kit
KA3966C

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Antigen&Target Information
Gene Name:
MMP12
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Other Name:
Macrophage metalloelastase ;
MME ;
Macrophage elastase ;
ME ;
hME ;
Matrix metalloproteinase-12 ;
MMP-12 ;
show all
Database Link:
Organism Gene ID SwissProt
Human 4321; P39900;
Mouse P34960;
Background:
catalytic activity:Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.,induction:By exposure to lipopolysaccharide. Inhibited by dexamethasone.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Found in alveolar macrophages but not in peripheral blood monocytes.,
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Function:
proteolysis, positive regulation of cell proliferation, regulation of cell proliferation, response to drug, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation,
show all
Cellular Localization:
Secreted, extracellular space, extracellular matrix .
show all
Tissue Expression:
Found in alveolar macrophages but not in peripheral blood monocytes.
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Catalog: KA3966C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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