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Cleaved Factor B Bb (Lys260) Cell-Based Colorimetric ELISA Kit

-KA3955C

Catalog: KA3955C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CFB
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Other Name:
Complement factor B ;
C3/C5 convertase ;
Glycine-rich beta glycoprotein ;
GBG ;
PBF2 ;
Properdin factor B ;
[Cleaved into: Complement factor B Ba fragment ;
Complement factor B Bb fragment]
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Database Link:
Organism Gene ID SwissProt
Human 629; P00751;
Mouse P04186;
Background:
catalytic activity:Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.,function:Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.,polymorphism:Two major variants, F and S, and 2 minor variants, as well as at least 14 very rare variants, have been identified. The variants His-9 and Gln-32 are associated with a reduced risk of age-related macular degeneration (ARMD) [MIM:603075]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 VWFA domain.,similarity:Contains 3 Sushi (CCP/SCR) domains.,subunit:Monomer.,
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Function:
immune effector process, activation of immune response, acute inflammatory response, activation of plasma proteins involved in acute inflammatory response, positive regulation of immune system process, proteolysis, defense response, inflammatory response, immune response, complement activation, complement activation, alternative pathway, humoral immune response, response to unfolded protein, response to nutrient, response to wounding,response to extracellular stimulus, response to organic substance, protein processing, response to nutrient levels,innate immune response, positive regulation of response to stimulus, positive regulation of immune response, protein maturation, protein maturation by peptide bond cleavage, response to protein stimulus,
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Cellular Localization:
Secreted.
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Catalog: KA3955C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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