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Cleaved Caspase-2 p18 (Thr325) Cell-Based Colorimetric ELISA Kit

-KA3935C

Catalog: KA3935C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CASP2
show all
Other Name:
Caspase-2 ;
CASP-2 ;
Neural precursor cell expressed developmentally down-regulated protein 2 ;
NEDD-2 ;
Protease ICH-1 ;
[Cleaved into: Caspase-2 subunit p18 ;
Caspase-2 subunit p13 ;
Caspase-2 subunit p12]
show all
Database Link:
Organism Gene ID SwissProt
Human 835; P42575;
Mouse P29594;
Rat P55215;
Background:
alternative products:Isoforms differ in the N- and C-termini,catalytic activity:Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.,PTM:The mature protease can process its own propeptide, but not that of other caspases.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD.,tissue specificity:Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.,
show all
Function:
proteolysis, apoptosis, anti-apoptosis, induction of apoptosis, cell death, induction of apoptosis by extracellular signals, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, death, protein processing, regulation of apoptosis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death, protein maturation, protein maturation by peptide bond cleavage, negative regulation of cell death,
show all
Tissue Expression:
Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
show all
Catalog: KA3935C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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