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Total CYP7B1 Cell-Based Colorimetric ELISA Kit

-KA3903C

Catalog: KA3903C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CYP7B1
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Other Name:
25-hydroxycholesterol 7-alpha-hydroxylase ;
Cytochrome P450 7B1 ;
Oxysterol 7-alpha-hydroxylase ;
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Database Link:
Organism Gene ID SwissProt
Human 9420; O75881;
Mouse Q60991;
Background:
catalytic activity:Cholest-5-ene-3-beta,25-diol + NADPH + O(2) = cholest-5-ene-3-beta,7-alpha,25-triol + NADP(+) + H(2)O.,catalytic activity:Cholest-5-ene-3-beta,27-diol + NADPH + O(2) = cholest-5-ene-3-beta,7-alpha,27-triol + NADP(+) + H(2)O.,cofactor:Heme group.,disease:Defects in CYP7B1 are the cause of congenital bile acid synthesis defect type 3 (CBAS3) [MIM:603711]. Clinical features include severe cholestasis, cirrhosis and liver synthetic failure. Hepatic microsomal oxysterol 7-alpha-hydroxylase activity is undetectable.,disease:Defects in CYP7B1 are the cause of spastic paraplegia autosomal recessive type 5A (SPG5A) [MIM:270800]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.,pathway:Lipid metabolism; bile acid biosynthesis.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Brain, testis, ovary, prostate, liver, colon, kidney, and small intestine.,
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Function:
steroid biosynthetic process, bile acid biosynthetic process, circadian rhythm, steroid metabolic process, cholesterol metabolic process, bile acid metabolic process, cell death, lipid biosynthetic process, response to organic substance,organic acid biosynthetic process, sterol metabolic process, death, response to drug, carboxylic acid biosynthetic process, rhythmic process, response to cAMP, oxidation reduction,
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Cellular Localization:
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein .
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Tissue Expression:
Widely expressed. Expressed in brain, testis, ovary, prostate, liver, colon, kidney, small intestine, thymus and spleen.
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Catalog: KA3903C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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