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Total CYP2R1 Cell-Based Colorimetric ELISA Kit

-KA3893C

Catalog: KA3893C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CYP2R1
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Other Name:
Vitamin D 25-hydroxylase ;
Cytochrome P450 2R1 ;
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Database Link:
Organism Gene ID SwissProt
Human 120227; Q6VVX0;
Mouse Q6VVW9;
Background:
catalytic activity:5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O(2) = (25R)-5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP(+) + H(2)O.,cofactor:Heme group.,disease:Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency (25HOD3D)[MIM:600081]; also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity, and low levels of 25-hydroxyvitamin D.,function:Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).,similarity:Belongs to the cytochrome P450 family.,subunit:Homodimer.,
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Function:
vitamin metabolic process, fat-soluble vitamin metabolic process, steroid metabolic process, vitamin D metabolic process, oxidation reduction,
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Cellular Localization:
Endoplasmic reticulum membrane ; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein.
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Catalog: KA3893C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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