Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

THBS1

Thrombospondin-1

THBS1 ;
TSP ;
TSP1 ;
Thrombospondin-1

function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen , fibronectin , laminin , type V collagen and integrins alpha-V/beta-1 , alpha-V/beta-3 and alpha-IIb/beta-3. ,similarity:Belongs to the thrombospondin family. ,similarity:Contains 1 TSP C-terminal (TSPC) domain. ,similarity:Contains 1 TSP N-terminal (TSPN) domain. ,similarity:Contains 1 VWFC domain. ,similarity:Contains 3 EGF-like domains. ,similarity:Contains 3 TSP type-1 domains. ,similarity:Contains 8 TSP type-3 repeats. ,subunit:Homotrimer; disulfide-linked. ,

MAPKKK cascade , activation of MAPK activity , angiogenesis , blood vessel development , response to hypoxia ,regulation of cytokine production , negative regulation of cytokine production , positive regulation of cytokine production , regulation of endothelial cell proliferation , negative regulation of endothelial cell proliferation , vasculature development , regulation of cell-matrix adhesion , negative regulation of cell-matrix adhesion , sprouting angiogenesis ,chronic inflammatory response , regulation of antigen processing and presentation , negative regulation of antigen processing and presentation , regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II , negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II , regulation of dendritic cell antigen processing and presentation , negative regulation of dendritic cell antigen processing and presentation , negative regulation of immune system process , positive regulation of immune system process , regulation of leukocyte migration , positive regulation of leukocyte migration , regulation of leukocyte chemotaxis , positive regulation of leukocyte chemotaxis , regulation of leukocyte activation , positive regulation of leukocyte activation , regulation of translation , protein amino acid phosphorylation , phosphorus metabolic process ,phosphate metabolic process , endocytosis , phagocytosis , phagocytosis , engulfment , apoptosis , anti-apoptosis , cell motion , defense response , inflammatory response , immune response , cell cycle , cell cycle arrest , cell adhesion ,negative regulation of cell adhesion , intracellular signaling cascade , protein kinase cascade , cell death , negative regulation of cell proliferation , response to temperature stimulus , response to heat , response to wounding , response to abiotic stimulus , response to endogenous stimulus , response to hormone stimulus , response to carbohydrate stimulus , response to hexose stimulus , response to glucose stimulus , positive regulation of biosynthetic process ,positive regulation of signal transduction , negative regulation of signal transduction , response to organic substance ,response to inorganic substance , response to metal ion , membrane invagination , positive regulation of macromolecule biosynthetic process , positive regulation of phosphorus metabolic process , regulation of endothelial cell migration ,positive regulation of endothelial cell migration , negative regulation of endothelial cell migration , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , posttranscriptional regulation of gene expression , positive regulation of cell communication , negative regulation of cell communication ,positive regulation of oxygen and reactive oxygen species metabolic process , regulation of plasma membrane long-chain fatty acid transport , negative regulation of plasma membrane long-chain fatty acid transport , regulation of nitric oxide mediated signal transduction , negative regulation of nitric oxide mediated signal transduction , regulation of cGMP-mediated signaling , negative regulation of cGMP-mediated signaling , regulation of plasminogen activation ,negative regulation of plasminogen activation , regulation of macrophage chemotaxis , positive regulation of macrophage chemotaxis , regulation of fibroblast migration , positive regulation of fibroblast migration , regulation of cell-substrate adhesion , positive regulation of cell-substrate adhesion , negative regulation of cell-substrate adhesion ,regulation of cell death , regulation of protein maturation by peptide bond cleavage , negative regulation of protein maturation by peptide bond cleavage , programmed cell death , membrane organization , vesicle-mediated transport ,death , phosphorylation , cell migration , negative regulation of angiogenesis , regulation of transforming growth factor beta receptor signaling pathway , peptide cross-linking , regulation of phosphate metabolic process , cell cycle process ,biological adhesion , regulation of cell adhesion , regulation of proteolysis , regulation of blood coagulation , positive regulation of blood coagulation , regulation of cell migration , positive regulation of cell migration , negative regulation of cell migration , positive regulation of transforming growth factor beta receptor signaling pathway , positive regulation of cellular biosynthetic process , response to magnesium ion , regulation of response to external stimulus , positive regulation of response to external stimulus , regulation of cellular protein metabolic process , negative regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , regulation of lipid transport , negative regulation of lipid transport , response to progesterone stimulus , regulation of interleukin-12 production , negative regulation of interleukin-12 production , regulation of organic acid transport , negative regulation of organic acid transport , regulation of transforming growth factor-beta1 production , positive regulation of transforming growth factor-beta1 production , cellular response to stress , positive regulation of kinase activity ,response to monosaccharide stimulus , cellular response to heat , regulation of locomotion , negative regulation of locomotion , positive regulation of locomotion , regulation of fibroblast growth factor receptor signaling pathway ,negative regulation of fibroblast growth factor receptor signaling pathway , regulation of cell proliferation , regulation of phosphorylation , positive regulation of phosphorylation , regulation of apoptosis , regulation of macrophage activation ,positive regulation of macrophage activation , negative regulation of apoptosis , regulation of programmed cell death ,negative regulation of programmed cell death , positive regulation of catalytic activity , apoptotic cell clearance ,regulation of MAP kinase activity , positive regulation of MAP kinase activity , regulation of blood vessel endothelial cell migration , positive regulation of blood vessel endothelial cell migration , negative regulation of blood vessel endothelial cell migration , regulation of kinase activity , engulfment of apoptotic cell , regulation of cellular component biogenesis ,positive regulation of molecular function , positive regulation of translation , regulation of angiogenesis , positive regulation of angiogenesis , positive regulation of cell adhesion , regulation of protein kinase activity , positive regulation of protein kinase activity , negative regulation of proteolysis , positive regulation of phosphate metabolic process , blood vessel morphogenesis , positive regulation of behavior , response to steroid hormone stimulus , positive regulation of response to stimulus , cell motility , regulation of behavior , regulation of coagulation , positive regulation of coagulation , regulation of cell activation , positive regulation of cell activation , regulation of chemotaxis , positive regulation of chemotaxis , negative regulation of transport , positive regulation of developmental process , negative regulation of cellular component organization , regulation of phosphorus metabolic process , positive regulation of multicellular organismal process , negative regulation of multicellular organismal process , positive regulation of protein metabolic process , negative regulation of protein metabolic process , regulation of cell motion , negative regulation of cell motion , positive regulation of cell motion , regulation of transferase activity , positive regulation of transferase activity , response to calcium ion , localization of cell , regulation of focal adhesion formation , negative regulation of focal adhesion formation , regulation of fibrinolysis , negative regulation of fibrinolysis , negative regulation of cell death ,response to oxygen levels , regulation of protein processing , regulation of oxygen and reactive oxygen species metabolic process ,

Secreted . Cell surface . Secreted , extracellular space , extracellular matrix . Endoplasmic reticulum . Sarcoplasmic reticulum . Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca (2+) (PubMed:6777381) . Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993) . Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity) . .