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Total CYP27A1 Cell-Based Colorimetric ELISA Kit

-KA3885C

Catalog: KA3885C
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96well
$330.00
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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CYP27A1
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Other Name:
Sterol 26-hydroxylase, mitochondrial ;
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase ;
Cytochrome P-450C27/25 ;
Cytochrome P450 27 ;
Sterol 27-hydroxylase ;
Vitamin D ;
3 ;
25-hydroxylase ;
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Database Link:
Organism Gene ID SwissProt
Human 1593; Q02318;
Mouse Q9DBG1;
Background:
catalytic activity:5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O(2) = (25R)-5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP(+) + H(2)O.,cofactor:Heme group.,disease:Defects in CYP27A1 are the cause of cerebrotendinous xanthomatosis (CTX) [MIM:213700]. CTX is a rare sterol storage disorder characterized clinically by progressive neurologic dysfunction, premature atherosclerosis, and cataracts.,function:Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.,pathway:Hormone biosynthesis; cholecalciferol biosynthesis.,similarity:Belongs to the cytochrome P450 family.,
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Function:
steroid metabolic process, cholesterol metabolic process, sterol metabolic process, oxidation reduction,
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Cellular Localization:
Mitochondrion inner membrane ; Peripheral membrane protein . Post-translationally targeted to mitochondria. All three of the receptor proteins in the TOM complex, TOMM70, TOMM20 and TOMM22 are required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. .
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Tissue Expression:
Expressed in the neural retina and underlying retinal pigment epithelium (at protein level) (PubMed:21411718). Expressed in the gray and white matter of cerebellum (at protein level) (PubMed:28190002).
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Catalog: KA3885C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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