CYP26A1

Cytochrome P450 26A1 ;
Cytochrome P450 retinoic acid-inactivating 1 ;
Cytochrome P450RAI ;
hP450RAI ;
Retinoic acid 4-hydroxylase ;
Retinoic acid-metabolizing cytochrome ;

cofactor:Heme group.,function:Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.,induction:By retinoic acid.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.,

retinoid metabolic process, regionalization, isoprenoid metabolic process, terpenoid metabolic process, vitamin metabolic process, fat-soluble vitamin metabolic process, vitamin A metabolic process, intracellular signaling cascade,pattern specification process, vitamin catabolic process, anterior/posterior pattern formation, negative regulation of signal transduction, negative regulation of cell communication, regulation of hormone levels, mesenchymal cell development, neural crest cell development, neural crest cell differentiation, diterpenoid metabolic process, secondary metabolic process, intracellular receptor-mediated signaling pathway, retinoic acid catabolic process, cellular hormone metabolic process, fat-soluble vitamin catabolic process, hormone metabolic process, retinoic acid metabolic process,retinoic acid receptor signaling pathway, regulation of retinoic acid receptor signaling pathway, negative regulation of retinoic acid receptor signaling pathway, mesenchymal cell differentiation, oxidation reduction, mesenchyme development,

Endoplasmic reticulum membrane ; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein.

Expressed in most fetal and adult tissues with highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain (PubMed:9826557). Expressed at high levels in lung, pancreas, skin and uterus (at protein level) (PubMed:22020119). Lower expression level is detected in spleen, kidney, intestine and adipose tissue (at protein level) (PubMed:22020119).