Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

TNFRSF1B

Tumor necrosis factor receptor superfamily member 1B

TNFRSF1B ;
TNFBR ;
TNFR2 ;
Tumor necrosis factor receptor superfamily member 1B ;
Tumor necrosis factor receptor 2 ;
TNF-R2 ;
Tumor necrosis factor receptor type II ;
TNF-RII ;
TNFR-II ;
p75 ;
p80 TNF-alpha receptor ;
CD antigen CD120b ;
Etanercept

function:Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis , which suggests that it regulates TNF-alpha function by antagonizing its biological activity. ,online information:Clinical information on Enbrel ,pharmaceutical:Available under the name Enbrel (Immunex and Wyeth-Ayerst) . Used to treat moderate to severe rheumatoid arthritis (RA) . Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors. ,PTM:A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. ,PTM:Phosphorylated; mainly on serine residues and with a very low level on threonine residues. ,similarity:Contains 4 TNFR-Cys repeats. ,subunit:Binds to TRAF2. ,

apoptosis , defense response , inflammatory response , immune response , cell surface receptor linked signal transduction , cell death , response to wounding , posttranscriptional regulation of gene expression , programmed cell death , death , negative regulation of defense response , regulation of response to external stimulus , negative regulation of response to external stimulus , regulation of RNA stability , negative regulation of response to stimulus ,regulation of inflammatory response , negative regulation of inflammatory response , RNA destabilization , regulation of RNA metabolic process ,

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Tumor necrosis factor-binding protein 2]: Secreted.