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Total CYP19A1 Cell-Based Colorimetric ELISA Kit

-KA3881C

Catalog: KA3881C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CYP19A1
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Other Name:
Cytochrome P450 19A1 ;
Aromatase ;
CYPXIX ;
Cytochrome P-450AROM ;
Estrogen synthase ;
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Database Link:
Organism Gene ID SwissProt
Human 1588; P11511;
Mouse P28649;
Rat P22443;
Background:
catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,disease:Defects in CYP19A1 are a cause of familial gynecomastia [MIM:139300]. This is characterized by an estrogen excess due to an increased aromatase activity.,disease:Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:107910]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.,function:Catalyzes the formation of aromatic C18 estrogens from C19 androgens.,online information:Aromatase entry,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Brain, placenta and gonads.,
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Function:
steroid biosynthetic process, steroid metabolic process, lipid biosynthetic process, oxidation reduction,
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Cellular Localization:
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein .
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Tissue Expression:
Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.
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Catalog: KA3881C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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