Catalog: KE1237
Size
Price
Status
Qty.
5*96well
$1,850.00
2 weeks
0
2*96well
$740.00
2 weeks
0
96well
$370.00
2 weeks
0
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Main Information
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Specificity
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Storage
2-8°C/6 months,Ship by ice bag
Modification
Unmodified
Sample Type
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Detection Method
Colorimetric
Sensitivity
32-2000 pg/ml
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Antigen&Target Information
Specificity:
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
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Gene Name:
MIF
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Protein Name:
Macrophage migration inhibitory factor
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Other Name:
MIF ;
GLIF ;
MMIF ;
Macrophage migration inhibitory factor ;
MIF ;
Glycosylation-inhibiting factor ;
GIF ;
L-dopachrome isomerase ;
L-dopachrome tautomerase ;
Phenylpyruvate tautomerase
GLIF ;
MMIF ;
Macrophage migration inhibitory factor ;
MIF ;
Glycosylation-inhibiting factor ;
GIF ;
L-dopachrome isomerase ;
L-dopachrome tautomerase ;
Phenylpyruvate tautomerase
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Background:
catalytic activity:Keto-phenylpyruvate = enol-phenylpyruvate. ,disease:Genetic variations in MIF are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe , debilitating , extraarticular features , and occasionally fatal complications. Despite medical treatment , many children still experience early joint destruction , necessitating surgical replacement. ,function:The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase. ,similarity:Belongs to the MIF family. ,subunit:Homotrimer. Interacts with COPS5 and BNIPL. ,
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Function:
prostaglandin biosynthetic process , regulation of leukocyte activation , protein complex assembly , fatty acid metabolic process , fatty acid biosynthetic process , unsaturated fatty acid biosynthetic process , icosanoid metabolic process ,prostanoid metabolic process , prostaglandin metabolic process , defense response , inflammatory response , immune response , cell surface receptor linked signal transduction , cell proliferation , lipid biosynthetic process , response to wounding , regulation of cell death , organic acid biosynthetic process , unsaturated fatty acid metabolic process ,regulation of apoptosis , regulation of macrophage activation , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , macromolecular complex subunit organization ,innate immune response , carboxylic acid biosynthetic process , icosanoid biosynthetic process , prostanoid biosynthetic process , regulation of cell activation , protein oligomerization , protein homooligomerization , negative regulation of cell death , macromolecular complex assembly , protein trimerization , protein homotrimerization , protein complex biogenesis ,
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Cellular Localization:
Secreted . Cytoplasm . Does not have a cleavable signal sequence and is secreted via a specialized , non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS) , or by M.tuberculosis antigens. .
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Reference Citation({{totalcount}})
Catalog: KE1237
Size
Price
Status
Qty.
5*96well
$1,850.00
2 weeks
0
2*96well
$740.00
2 weeks
0
96well
$370.00
2 weeks
0
Add to cart
Collected
Collect
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