Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

AHSG FETUA PRO2743

Alpha-2-HS-glycoprotein

AHSG ;
FETUA ;
Alpha-2-HS-glycoprotein ;
Alpha-2-Z-globulin ;
Ba-alpha-2-glycoprotein ;
Fetuin-A ;
[Cleaved into: Alpha-2-HS-glycoprotein chain A ;
Alpha-2-HS-glycoprotein chain B]

function:Promotes endocytosis , possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. ,polymorphism:There are two common alleles , AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256. ,similarity:Belongs to the fetuin family. ,similarity:Contains 2 cystatin domains. ,subunit:Alpha-2-HS glycoprotein derives from this precursor , when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. ,tissue specificity:Synthesized in liver and selectively concentrated in bone matrix. Secrete din plasma. It is also found in dentin in much higher quantities than other plasma proteins. ,

skeletal system development , ossification , acute inflammatory response , reproductive developmental process ,endocytosis , pinocytosis , defense response , acute-phase response , inflammatory response , sex differentiation , gonad development , male gonad development , response to wounding , response to endogenous stimulus , response to hormone stimulus , negative regulation of signal transduction , response to organic substance , membrane invagination ,negative regulation of cell communication , membrane organization , vesicle-mediated transport , telencephalon development , pallium development , cerebral cortex development , regulation of endocytosis , regulation of ossification ,negative regulation of ossification , regulation of bone mineralization , negative regulation of bone mineralization ,forebrain development , regulation of response to external stimulus , regulation of homeostatic process , positive regulation of homeostatic process , response to insulin stimulus , cellular response to insulin stimulus , cellular response to hormone stimulus , regulation of tissue remodeling , positive regulation of tissue remodeling , response to peptide hormone stimulus , regulation of bone resorption , development of primary sexual characteristics , positive regulation of bone resorption , positive regulation of endocytosis , development of primary male sexual characteristics , regulation of insulin receptor signaling pathway , negative regulation of insulin receptor signaling pathway , male sex differentiation ,regulation of bone remodeling , positive regulation of bone remodeling , negative regulation of response to stimulus ,reproductive structure development , regulation of inflammatory response , regulation of phagocytosis , positive regulation of phagocytosis , positive regulation of transport , positive regulation of cellular component organization ,positive regulation of multicellular organismal process , negative regulation of multicellular organismal process , bone development , regulation of vesicle-mediated transport , regulation of biomineral formation , negative regulation of biomineral formation ,

Secreted.