Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CXCL12

Stromal cell-derived factor 1

CXCL12 ;
SDF1 ;
SDF1A ;
SDF1B ;
Stromal cell-derived factor 1 ;
SDF-1 ;
hSDF-1 ;
C-X-C motif chemokine 12 ;
Intercrine reduced in hepatomas ;
IRH ;
hIRH ;
Pre-B cell growth-stimulating factor ;
PBSF

function:Chemoattractant active on T-lymphocytes , monocytes , but not neutrophils. SDF-1-beta (3-72) and SDF-1-alpha (3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha (3-67) and thus to preserve activity on local sites. ,online information:SDF-1 entry ,PTM:Processed forms SDF-1-beta (3-72) and SDF-1-alpha (3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha , respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha (1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and , probably , cell surface proteoglycans. ,similarity:Belongs to the intercrine alpha (chemokine CxC) family. ,

cell morphogenesis , cell morphogenesis involved in differentiation , angiogenesis , blood vessel development ,patterning of blood vessels , ameboidal cell migration , morphogenesis of a branching structure , neuron migration , cell activation , vasculature development , positive regulation of immune system process , regulation of leukocyte migration ,positive regulation of leukocyte migration , regulation of leukocyte chemotaxis , positive regulation of leukocyte chemotaxis , reproductive developmental process , circulatory system process , cellular ion homeostasis , cellular calcium ion homeostasis , cellular metal ion homeostasis , cell motion , chemotaxis , immune response , cell adhesion , cell surface receptor linked signal transduction , G-protein coupled receptor protein signaling pathway , gamete generation , germ cell development , pattern specification process , axonogenesis , axon guidance , behavior , locomotory behavior , blood circulation , motor axon guidance , regulation of actin polymerization or depolymerization , cell proliferation , germ cell migration , response to virus , cell migration , cellular homeostasis , sexual reproduction , biological adhesion , cellular cation homeostasis , cellular di- , tri-valent inorganic cation homeostasis , cell projection organization , neuron differentiation , regulation of cell migration , positive regulation of cell migration , regulation of actin filament length ,neuron projection development , regulation of response to external stimulus , positive regulation of response to external stimulus , multicellular organism reproduction , regulation of cellular component size , mononuclear cell proliferation , regulation of actin cytoskeleton organization , regulation of actin filament-based process , cellular component morphogenesis , cell part morphogenesis , regulation of organelle organization , tube morphogenesis , tube development , regulation of locomotion , positive regulation of locomotion , T cell proliferation , T cell activation , taxis ,homeostatic process , leukocyte activation , lymphocyte activation , lymphocyte proliferation , blood vessel morphogenesis , positive regulation of behavior , positive regulation of response to stimulus , reproductive process in a multicellular organism , reproductive cellular process , neuron development , cell morphogenesis involved in neuron differentiation , branching morphogenesis of a tube , neuron projection morphogenesis , cell projection morphogenesis ,cell motility , chemical homeostasis , regulation of behavior , ion homeostasis , regulation of chemotaxis , positive regulation of chemotaxis , regulation of positive chemotaxis , positive regulation of positive chemotaxis , induction of positive chemotaxis , regulation of cell motion , positive regulation of cell motion , regulation of cytoskeleton organization , localization of cell , metal ion homeostasis , di- , tri-valent inorganic cation homeostasis , calcium ion homeostasis , cation homeostasis , cellular chemical homeostasis , leukocyte proliferation ,

Secreted.