Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CLU

Clusterin

CLU ;
APOJ ;
CLI ;
KUB1 ;
AAG4 ;
Clusterin ;
Aging-associated gene 4 protein ;
Apolipoprotein J ;
Apo-J ;
Complement cytolysis inhibitor ;
CLI ;
Complement-associated protein SP-40 ;
40 ;
Ku70-binding protein 1 ;
NA1/NA2 ;
Testosterone-repressed prostate m

function:Not yet clear. It is known to be expressed in a variety of tissues and it seems to be able to bind to cells , membranes and hydrophobic proteins. It has been associated with programmed cell death (apoptosis) . ,similarity:Belongs to the clusterin family. ,subunit:Antiparallel disulfide-linked heterodimer. Interacts with APOA1 , CLUAP1 AND PON1. ,

cell morphogenesis , release of cytochrome c from mitochondria , adaptive immune response , immune effector process ,activation of immune response , leukocyte mediated immunity , lymphocyte mediated immunity , humoral immune response mediated by circulating immunoglobulin , adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , acute inflammatory response , activation of plasma proteins involved in acute inflammatory response , positive regulation of immune system process , proteolysis , lipid transport , apoptosis , anti-apoptosis , defense response , inflammatory response , immune response , complement activation , complement activation , classical pathway , humoral immune response , response to oxidative stress ,mitochondrion organization , cell death , positive regulation of cell proliferation , apoptotic mitochondrial changes ,response to wounding , lipid localization , regulation of cell death , programmed cell death , sterol transport ,immunoglobulin mediated immune response , death , protein processing , B cell mediated immunity , cell projection organization , neuron differentiation , cholesterol transport , pancreas development , endocrine pancreas development ,neuron projection development , negative regulation of protein complex assembly , regulation of protein oligomerization , negative regulation of protein oligomerization , regulation of protein homooligomerization , negative regulation of protein homooligomerization , cellular component morphogenesis , cell part morphogenesis , endocrine system development , regulation of cell proliferation , regulation of apoptosis , negative regulation of apoptosis ,regulation of programmed cell death , negative regulation of programmed cell death , regulation of protein complex assembly , reverse cholesterol transport , regulation of cellular component biogenesis , innate immune response ,positive regulation of cell differentiation , positive regulation of response to stimulus , neuron development , neuron projection morphogenesis , cell projection morphogenesis , positive regulation of immune response , positive regulation of developmental process , negative regulation of cellular component organization , protein maturation , protein maturation by peptide bond cleavage , negative regulation of cell death ,

[Isoform 1]: Secreted . Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. .; [Isoform 4]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .; [Isoform 6]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .; Nucleus . Cytoplasm . Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm , cytosol . Microsome . Endoplasmic reticulum . Mitochondrion . Mitochondrion membrane . Cytoplasm , perinuclear region . Cytoplasmic vesicle , secretory vesicle , chromaffin granule . Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress (PubMed:17451556) . Detected in perinuclear foci that may be aggresomes containing misfolded , ubiquitinated proteins (PubMed:20068069) . Detected at the mitochondrion membrane upon induction of apoptosis (PubMed:17689225) . Under ER stress , a immaturely glycosylated pre-secreted form retrotranslocates from the endoplasmic reticulum (ER) -Golgi network to the cytoplasm to localize in the mitochondria through HSPA5 interaction (PubMed:22689054) . ER stress reduces secretion (PubMed:22689054) . Under the stress , minor amounts of non-secreted forms accumulate in cytoplasm (PubMed:24073260 , PubMed:22689054 , PubMed:17451556) . Non-secreted forms emerge mainly from failed translocation , alternative splicing or non-canonical initiation start codon (PubMed:24073260 , PubMed:12551933) . .